Light-Accelerated Iridium-Catalyzed C–H Borylation

IF 13.6 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2026-10-16 Epub Date: 2026-10-02 DOI:10.1021/acscatal.6c04883

Máire Griffin, Hrithik Manojkumar, Tabea Heil, Stuart A. Macgregor, Eric Slack, Eli Zysman Colman

引用次数: 0

Abstract

Here, we report a mild, light-assisted iridium-catalyzed C–H borylation protocol for organic substrates. We demonstrate that adapting the Ishiyama–Tagaki–Miyaura–Hartwig (ITMH) protocol for C–H borylation to proceed under photochemical conditions imparts a pronounced rate enhancement compared to the established dark reaction. This photochemistry methodology achieves higher yields across a broad range of substrates and is easily scalable using continuous flow technology.

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光加速铱催化C-H硼化反应

在这里，我们报道了一种温和的，光辅助铱催化的有机底物C-H硼化反应方案。我们证明了在光化学条件下采用Ishiyama-Tagaki-Miyaura-Hartwig （ITMH）方案进行C-H硼化反应，与既定的暗反应相比，可以显著提高反应速率。这种光化学方法在广泛的衬底上实现了更高的产量，并且使用连续流技术易于扩展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.