Chitosan oligosaccharides in antibacterial applications: Decoupling material properties, antimicrobial mechanisms, and host responses

IF 6.4 1区农林科学 Q1 AGRICULTURAL ENGINEERING

Industrial Crops and Products Pub Date : 2026-10-01 Epub Date: 2026-10-06 DOI:10.1016/j.indcrop.2026.124524

Yipeng Wang, Meng Zhang, Yihan Wang, Tianshu Wang, Jiayun Zou, Ying Xi, Yibo Bai

{"title":"Chitosan oligosaccharides in antibacterial applications: Decoupling material properties, antimicrobial mechanisms, and host responses","authors":"Yipeng Wang, Meng Zhang, Yihan Wang, Tianshu Wang, Jiayun Zou, Ying Xi, Yibo Bai","doi":"10.1016/j.indcrop.2026.124524","DOIUrl":null,"url":null,"abstract":"<div><div>Chitosan oligosaccharide (COS) is a low-molecular-weight hydrolysate derived from chitin and chitosan through chemical hydrolysis or enzymatic degradation. Compared with its parent polymers (chitin and chitosan) and other common natural polysaccharides, COS displays prominent water solubility, favorable biocompatibility, and multiple biofunctions including antibacterial, antioxidant and anti-inflammatory. Derivatization strategies for COS effectively strengthen its performance as carriers for drugs and genes, further expanding its applicable scope within pharmaceutics, food science and biomaterial engineering. This article reviews the preparation methods, structural characteristics, physicochemical properties, antimicrobial mechanisms, and clinical applications of COS as an antimicrobial agent. Integrating recent literature, it comprehensively analyzes and discusses the antimicrobial mechanisms of COS, key factors influencing its antimicrobial activity, and future development trends, aiming to evaluate its medical value and provide direction for its fundamental research and clinical translation.</div></div>","PeriodicalId":13581,"journal":{"name":"Industrial Crops and Products","volume":"252 ","pages":"Article 124524"},"PeriodicalIF":6.4000,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Industrial Crops and Products","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0926669026019138","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/10/6 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"AGRICULTURAL ENGINEERING","Score":null,"Total":0}

引用次数: 0

Abstract

Chitosan oligosaccharide (COS) is a low-molecular-weight hydrolysate derived from chitin and chitosan through chemical hydrolysis or enzymatic degradation. Compared with its parent polymers (chitin and chitosan) and other common natural polysaccharides, COS displays prominent water solubility, favorable biocompatibility, and multiple biofunctions including antibacterial, antioxidant and anti-inflammatory. Derivatization strategies for COS effectively strengthen its performance as carriers for drugs and genes, further expanding its applicable scope within pharmaceutics, food science and biomaterial engineering. This article reviews the preparation methods, structural characteristics, physicochemical properties, antimicrobial mechanisms, and clinical applications of COS as an antimicrobial agent. Integrating recent literature, it comprehensively analyzes and discusses the antimicrobial mechanisms of COS, key factors influencing its antimicrobial activity, and future development trends, aiming to evaluate its medical value and provide direction for its fundamental research and clinical translation.

查看原文本刊更多论文

壳聚糖在抗菌中的应用：解耦材料特性、抗菌机制和宿主反应

壳聚糖低聚糖（COS）是甲壳素和壳聚糖经化学水解或酶降解而成的低分子量水解产物。与其母体聚合物（几丁质和壳聚糖）及其他常见的天然多糖相比，COS具有良好的水溶性、良好的生物相容性以及抗菌、抗氧化、抗炎等多种生物功能。COS的衍生化策略有效增强了其作为药物和基因载体的性能，进一步扩大了其在制药、食品科学和生物材料工程等领域的应用范围。本文综述了COS抗菌药物的制备方法、结构特点、理化性质、抗菌机理及临床应用。结合近期文献，全面分析和探讨COS的抑菌机制、影响其抑菌活性的关键因素及未来发展趋势，评价其医学价值，为其基础研究和临床转化提供方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Industrial Crops and Products 农林科学-农业工程

CiteScore

9.50

自引率

8.50%

发文量

1518

审稿时长

43 days

期刊介绍： Industrial Crops and Products is an International Journal publishing academic and industrial research on industrial (defined as non-food/non-feed) crops and products. Papers concern both crop-oriented and bio-based materials from crops-oriented research, and should be of interest to an international audience, hypothesis driven, and where comparisons are made statistics performed.