Rapid Motility Arrest of the Lyme Disease Spirochete, Borrelia burgdorferi , by Vaccine‐Induced OspA Antibodies

IF 3.1 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Microbiology Pub Date : 2026-10-06 DOI:10.1111/mmi.70122

Ankita Bhattacharyya,Raymond Yau,Thomas M. Bartlett,Nicholas J. Mantis

引用次数: 0

Abstract

ABSTRACT Outer surface protein A (OspA)‐based Lyme disease vaccines elicit antibodies that inhibit transmission of infectious Borrelia burgdorferi spirochetes from ticks to humans, although the mechanism by which this occurs is unclear. Here we demonstrate using high‐resolution, single‐cell fluorescence video microscopy that B. burgdorferi motility is arrested within minutes by human OspA‐specific monoclonal antibodies and polyclonal OspA antisera from mice immunized with a candidate OspA mRNA lipid nanoparticle vaccine.

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通过疫苗诱导的OspA抗体快速抑制莱姆病螺旋体伯氏疏螺旋体的运动

基于外表面蛋白A （OspA）的莱姆病疫苗可引发抗体，抑制感染性伯氏疏螺旋体从蜱虫传播给人类，尽管其发生的机制尚不清楚。本研究使用高分辨率单细胞荧光视频显微镜证明，用候选OspA mRNA脂质纳米颗粒疫苗免疫小鼠的人OspA特异性单克隆抗体和多克隆OspA抗血清在几分钟内抑制伯氏疏螺旋体的运动。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Microbiology 生物-生化与分子生物学

CiteScore

7.20

自引率

5.60%

发文量

132

审稿时长

1.7 months

期刊介绍： Molecular Microbiology, the leading primary journal in the microbial sciences, publishes molecular studies of Bacteria, Archaea, eukaryotic microorganisms, and their viruses. Research papers should lead to a deeper understanding of the molecular principles underlying basic physiological processes or mechanisms. Appropriate topics include gene expression and regulation, pathogenicity and virulence, physiology and metabolism, synthesis of macromolecules (proteins, nucleic acids, lipids, polysaccharides, etc), cell biology and subcellular organization, membrane biogenesis and function, traffic and transport, cell-cell communication and signalling pathways, evolution and gene transfer. Articles focused on host responses (cellular or immunological) to pathogens or on microbial ecology should be directed to our sister journals Cellular Microbiology and Environmental Microbiology, respectively.