Activins and BMPs: The yin and yang of diffuse midline gliomas

IF 23.3 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2026-10-01 DOI:10.1016/j.stem.2026.09.002

Kavya Prasad,Oren J. Becher

引用次数: 0

Abstract

Patient-derived models of diffuse midline gliomas (DMGs) remain challenging for interrogating tumor biology and investigating novel therapeutics. Xie et al. develop a robust patient-derived brainstem glioma organoid (BSGO) platform, reveal an Activin B-ACVR2A signaling pathway that promotes DMG growth, and identify a promising triple intrathecal therapy to inhibit it.

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激活素与bmp：弥漫性中线胶质瘤的阴阳关系

患者来源的弥漫性中线胶质瘤（dmg）模型仍然具有挑战性，质疑肿瘤生物学和研究新的治疗方法。Xie等人开发了一个强大的患者源性脑干胶质瘤类器官（BSGO）平台，揭示了激活素B-ACVR2A信号通路促进DMG生长，并确定了一种有前景的三重鞘内治疗来抑制它。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.