Right size, right time: The Hippo-IGF2 axis calibrates liver growth and regeneration

IF 23.3 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2026-10-01 DOI:10.1016/j.stem.2026.08.013

Wolfram Goessling

引用次数: 0

Abstract

The imprinted gene IGF2 is a well-characterized growth factor regulating organ proliferation during embryogenesis, while Hippo signaling has been demonstrated as an important regulator of organ size. This study by Zhong et al.1 mechanistically connects Hippo-controlled Igf2 expression in postnatal liver growth and regeneration.

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合适的大小，合适的时间：希波- igf2轴校准肝脏生长和再生

印迹基因IGF2是胚胎发生过程中调节器官增殖的生长因子，而Hippo信号已被证明是器官大小的重要调节因子。Zhong等人的这项研究将hippo控制的Igf2表达与出生后肝脏生长和再生联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.