Glutamine metabolism keeps pathogenic hepatic CD4+ T cells in check

IF 37 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2026-10-06 DOI:10.1016/j.cmet.2026.09.004

Haiguang Wang,Andrew Hakeem,Xavier S. Revelo

引用次数: 0

Abstract

Sawada et al. show that glutamine metabolism through glutaminolysis restrains O-GlcNAcylation and pathogenic inflammatory cytokine production by hepatic CD4+ T cells during MASLD. Glutamine supplementation restores hepatic glutamine availability and limits liver injury, and these findings reveal a tissue-specific metabolic checkpoint that restrains inflammatory T cell function during steatohepatitis.

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谷氨酰胺代谢使致病性肝CD4+ T细胞受到控制

Sawada等人的研究表明，在MASLD期间，谷氨酰胺通过谷氨酰胺水解代谢抑制了肝CD4+ T细胞的o - glcn酰化和致病性炎性细胞因子的产生。补充谷氨酰胺可恢复肝脏谷氨酰胺可用性并限制肝损伤，这些发现揭示了脂肪性肝炎期间组织特异性代谢检查点可抑制炎症T细胞功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.