Diet-microbiome interactions enhance cancer immunotherapy in obesity

IF 37 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2026-10-06 DOI:10.1016/j.cmet.2026.08.021

Allard W.J. van Renterghem,Emile E. Voest

引用次数: 0

Abstract

In a recent issue of Nature, Desharnais and colleagues show that diet-dependent remodeling of the gut microbiome promotes anti-tumor immunity and may explain the enhanced efficacy of immune checkpoint blockade observed in obesity. Their study identifies dietary intervention as a promising strategy to optimize the host for cancer immunotherapy.

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饮食-微生物组的相互作用增强了肥胖患者的癌症免疫治疗

在最近一期的《自然》杂志上，Desharnais和他的同事们表明，肠道微生物群的饮食依赖性重塑促进了抗肿瘤免疫，这可能解释了在肥胖中观察到的免疫检查点阻断的增强功效。他们的研究确定饮食干预是一种很有前途的策略，可以优化癌症免疫治疗的宿主。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.