A Ca2+ sensor-transcription factor cascade regulates cell-wall fortification and broad-spectrum disease resistance in rice

IF 9.2 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2026-10-07 DOI:10.1016/j.devcel.2026.09.006

Han Lu,Zian Ye,Yonglin Wu,Yuxin Fan,Yangxuan Liu,Xianmiao Zhu,Xi Zhang,Kui Li,Lingna Shangguan,Jingyi Wang,Weixuan Cui,Tianyi Ji,Shuai Tao,Xinxin Xie,Jiyun Liu,Yunjun Zhao,Weibing Yang,Ying Wang,Zuhua He,Mingjun Gao

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引用次数: 0

Abstract

Crop production is persistently threatened by a multitude of destructive diseases. In rice, the Ca2+ sensor RESISTANCE OF RICE TO DISEASES1 (ROD1) is a key regulator of defense against major pathogens, including those causing blast, sheath blight, and bacterial blight. However, the molecular mechanisms underlying ROD1-mediated immune suppression remain largely elusive. Here, we characterize an immune signaling cascade comprising the B3-domain transcription factor OsVAL2, the DOF transcription factor OsDOF3, as well as their downstream target OsCSE encoding a caffeoyl shikimate esterase. We demonstrate that the OsVAL2-OsDOF3-OsCSE module promotes lignin deposition and cell-wall fortification to confer broad-spectrum disease resistance. ROD1 interacts with and sequesters OsVAL2 in the cytoplasm, thereby preventing its nuclear accumulation and subsequent initiation of this immune program. Our findings reveal a spatiotemporal regulatory mechanism that maintains immune homeostasis, highlighting the crucial role of cell-wall remodeling in crop disease resistance.

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Ca2+传感器转录因子级联调节水稻细胞壁强化和广谱抗病性

农作物生产持续受到多种破坏性疾病的威胁。在水稻中，水稻抗病Ca2+传感器1 （ROD1）是防御主要病原体的关键调节因子，包括引起稻瘟病、鞘枯病和细菌性枯萎病的病原体。然而，rod1介导的免疫抑制的分子机制在很大程度上仍然难以捉摸。在这里，我们描述了一个免疫信号级联，包括b3结构域转录因子OsVAL2， DOF转录因子OsDOF3，以及它们的下游目标osse编码咖啡酰基shikimate酯酶。我们证明OsVAL2-OsDOF3-OsCSE模块促进木质素沉积和细胞壁强化，从而赋予广谱抗病能力。ROD1与细胞质中的OsVAL2相互作用并将其隔离，从而阻止其核积累和随后启动该免疫程序。我们的研究结果揭示了维持免疫稳态的时空调节机制，强调了细胞壁重塑在作物抗病中的关键作用。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.