Lactic acidosis in skeletal muscle contributes to sarcopenia

IF 33.7 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2026-10-05 DOI:10.1038/s41584-026-01448-5

Sarah Onuora

引用次数: 0

Abstract

Research in mice implicates lactic acidosis in skeletal muscle, caused by impaired metabolism of lactate in the liver, as a pathogenic mechanism of sarcopenia.

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骨骼肌乳酸酸中毒导致肌肉减少症

小鼠研究表明，肝脏乳酸代谢受损引起的骨骼肌乳酸酸中毒是肌肉减少症的一种致病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.