EVIDENCE OF CLL DEVELOPMENT FROM HEMATOPOIETIC PROGENITOR CELLS IN HUMANS

IF 23.9 1区医学 Q1 HEMATOLOGY

Blood Pub Date : 2026-10-06 DOI:10.1182/blood.2026034234

Francesca Gandini,Chiara Lenzi,Elisavet Vlachonikola,Lorenza Pecciarini,Anna Talarico,Andrea Demarchi,Lydia Scarfò,Michela Frenquelli,Kostas Stamatopoulos,Massimo Pini,Paolo Ghia

引用次数: 0

Abstract

Two siblings developed CLL after allogeneic transplantation from one to the other. Despite sharing the same precursors, the CLL clones displayed distinct IG gene rearrangements and genomic aberrations. Shared MED12 and NOTCH1 mutations suggest NOTCH pathway involvement in disease predisposition.

查看原文本刊更多论文

人类造血祖细胞发展CLL的证据

两个兄弟姐妹在异体移植后患上了CLL。尽管具有相同的前体，CLL克隆表现出不同的IG基因重排和基因组畸变。MED12和NOTCH1共同突变提示NOTCH通路参与疾病易感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Blood 医学-血液学

CiteScore

23.60

自引率

3.90%

发文量

955

审稿时长

1 months

期刊介绍： Blood, the official journal of the American Society of Hematology, published online and in print, provides an international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology. Primary research articles will be published under the following scientific categories: Clinical Trials and Observations; Gene Therapy; Hematopoiesis and Stem Cells; Immunobiology and Immunotherapy scope; Myeloid Neoplasia; Lymphoid Neoplasia; Phagocytes, Granulocytes and Myelopoiesis; Platelets and Thrombopoiesis; Red Cells, Iron and Erythropoiesis; Thrombosis and Hemostasis; Transfusion Medicine; Transplantation; and Vascular Biology. Papers can be listed under more than one category as appropriate.