The origins of rare glycosylphosphatidylinositol-deficient cells in normal and immune-mediated hematopoiesis

IF 23.9 1区医学 Q1 HEMATOLOGY

Blood Pub Date : 2026-10-07 DOI:10.1182/blood.2026033685

Yoshitaka Zaimoku,Dung Cao Tran,Kazuyoshi Hosomichi,Hiroki Mizumaki,Yui Kano,Miku Kobayashi,Eriko Morishita,Tatsuya Imi,Kohei Hosokawa,Yasuhito Nannya,Seishi Ogawa,Hirohito Yamazaki,Toshihiro Miyamoto,Shinji Nakao

引用次数: 0

Abstract

Single-cell-resolution PIGA sequencing showed that rare glycosylphosphatidylinositol-deficient cells in healthy individuals are polyclonal, comprising long-lived hematopoietic stem/progenitor-derived clones and nonpersistent populations. Those in acquired aplastic anemia reflect the selective expansion of multipotent PIGA-mutant stem/progenitor cells across myeloid and lymphoid lineages.

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正常和免疫介导造血中罕见的糖基磷脂酰肌醇缺陷细胞的起源

单细胞分辨率PIGA测序显示，健康个体中罕见的糖基磷脂酰肌醇缺陷细胞是多克隆的，包括长寿命的造血干细胞/祖细胞衍生克隆和非持久性群体。获得性再生障碍性贫血反映了多能性piga突变干细胞/祖细胞在髓系和淋巴系中的选择性扩增。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood 医学-血液学

CiteScore

23.60

自引率

3.90%

发文量

955

审稿时长

1 months

期刊介绍： Blood, the official journal of the American Society of Hematology, published online and in print, provides an international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology. Primary research articles will be published under the following scientific categories: Clinical Trials and Observations; Gene Therapy; Hematopoiesis and Stem Cells; Immunobiology and Immunotherapy scope; Myeloid Neoplasia; Lymphoid Neoplasia; Phagocytes, Granulocytes and Myelopoiesis; Platelets and Thrombopoiesis; Red Cells, Iron and Erythropoiesis; Thrombosis and Hemostasis; Transfusion Medicine; Transplantation; and Vascular Biology. Papers can be listed under more than one category as appropriate.