Urinary cadmium exposure and biomarkers of inflammation, lipid peroxidation, and kidney injury in apparently healthy adults from the Central Region of Mexico

IF 4.6 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2026-10-01 Epub Date: 2026-09-30 DOI:10.1016/j.etap.2026.105182

N. Pérez-Maldonado Iván, De la Trinidad-Chacón Carlos G, Rangel-Ramírez Velia V, C. Ochoa-Martínez Angeles, Varela-Silva José Antonio

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Abstract

Human exposure to cadmium remains a major global public health concern because of its potential to induce multiple adverse health effects. This study investigated the associations between cadmium exposure and effect biomarkers of oxidative stress, inflammation, and renal injury in a population from the Central Region of Mexico. The mean urinary cadmium concentration was 0.55 ± 1.15 µg/g creatinine. Higher urinary cadmium concentrations were significantly associated with increased levels of biomarkers of oxidative stress, inflammation, and kidney injury. These findings indicate that cadmium exposure is associated with biological alterations linked to an elevated risk of renal impairment, cardiovascular events, and metabolic syndrome, potentially mediated by oxidative stress and a sustained pro-inflammatory state. Overall, these findings highlight the importance of implementing public health strategies to reduce cadmium exposure and mitigate its potential contribution to the development of non-communicable diseases.

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墨西哥中部地区健康成人尿镉暴露与炎症、脂质过氧化和肾损伤的生物标志物

人类接触镉仍然是一个主要的全球公共卫生问题，因为它可能引起多种不利的健康影响。本研究调查了墨西哥中部地区人群中镉暴露与氧化应激、炎症和肾损伤效应生物标志物之间的关系。尿镉平均浓度为0.55 ± 1.15 µg/g肌酐。较高的尿镉浓度与氧化应激、炎症和肾损伤的生物标志物水平升高显著相关。这些发现表明，镉暴露与与肾损害、心血管事件和代谢综合征风险升高相关的生物学改变有关，可能由氧化应激和持续的促炎状态介导。总的来说，这些发现突出了实施公共卫生战略以减少镉暴露并减轻其对非传染性疾病发展的潜在贡献的重要性。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.