Identification of novel autoantibodies in Parkinson’s disease using a functional protein array platform

IF 8.5 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2026-10-02 DOI:10.1038/s41531-026-01568-5

Yin Xia Chao, Bernett TK Lee, Suh Yee Goh, Muhammad Yaaseen Gulam, Jolene SY Tan, Anis Larbi, Lei Feng, Ee-Wei Lim, Kumar M. Prakash, Louis C. S. Tan, Olaf Rötzschke, Jonathan M. Blackburn, Eng-King Tan

{"title":"Identification of novel autoantibodies in Parkinson’s disease using a functional protein array platform","authors":"Yin Xia Chao, Bernett TK Lee, Suh Yee Goh, Muhammad Yaaseen Gulam, Jolene SY Tan, Anis Larbi, Lei Feng, Ee-Wei Lim, Kumar M. Prakash, Louis C. S. Tan, Olaf Rötzschke, Jonathan M. Blackburn, Eng-King Tan","doi":"10.1038/s41531-026-01568-5","DOIUrl":null,"url":null,"abstract":"Autoimmunity has been implicated in Parkinson’s disease (PD), but the role of peripheral autoantibodies is unclear. Using a novel autoantibody screening platform (based on 3D protein structures), a 2-stage case-control study was conducted to identify peripheral autoantibodies in PD. 340 subjects, comprising of 140 age-and-gender-matched participants (50 PD patients and 90 healthy controls (HCs)) in the discovery cohort and a validation cohort involving 200 participants (110 PD patients and 90 HCs) were recruited. A two-pronged analysis approach and gender-corrected analysis identified increased levels of twelve autoantibodies in more PD patients’ plasmas than HCs. A transcriptomic meta-analysis, consisting of 62 datasets, confirmed the dysregulation of these targets in the blood and/or brain of PD patients. STRING analysis revealed that these targets mediate translation regulation and endothelial cell activity and vascular development/angiogenesis. These autoantibodies may be useful as potential diagnostic markers and/or targets for further pathophysiologic and therapeutic studies in PD.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"13 1","pages":""},"PeriodicalIF":8.5000,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"NPJ Parkinson's Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41531-026-01568-5","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Autoimmunity has been implicated in Parkinson’s disease (PD), but the role of peripheral autoantibodies is unclear. Using a novel autoantibody screening platform (based on 3D protein structures), a 2-stage case-control study was conducted to identify peripheral autoantibodies in PD. 340 subjects, comprising of 140 age-and-gender-matched participants (50 PD patients and 90 healthy controls (HCs)) in the discovery cohort and a validation cohort involving 200 participants (110 PD patients and 90 HCs) were recruited. A two-pronged analysis approach and gender-corrected analysis identified increased levels of twelve autoantibodies in more PD patients’ plasmas than HCs. A transcriptomic meta-analysis, consisting of 62 datasets, confirmed the dysregulation of these targets in the blood and/or brain of PD patients. STRING analysis revealed that these targets mediate translation regulation and endothelial cell activity and vascular development/angiogenesis. These autoantibodies may be useful as potential diagnostic markers and/or targets for further pathophysiologic and therapeutic studies in PD.

查看原文本刊更多论文

利用功能蛋白阵列平台鉴定帕金森病的新型自身抗体

自身免疫与帕金森病（PD）有关，但外周自身抗体的作用尚不清楚。利用一种新的自身抗体筛选平台（基于3D蛋白结构），进行了两期病例对照研究，以鉴定PD患者的外周自身抗体。在发现队列中招募了340名受试者，包括140名年龄和性别匹配的参与者（50名PD患者和90名健康对照者），在验证队列中招募了200名参与者（110名PD患者和90名hc）。双管齐下的分析方法和性别校正分析发现，PD患者血浆中的12种自身抗体水平高于hc患者。一项包含62个数据集的转录组荟萃分析证实了PD患者血液和/或大脑中这些靶标的失调。STRING分析显示，这些靶点介导翻译调控、内皮细胞活性和血管发育/血管生成。这些自身抗体可作为PD的潜在诊断标记和/或进一步病理生理和治疗研究的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.