Cognitive impairment in Parkinson’s disease: prevalence and associations with cardiometabolic, vascular, and autonomic factors—a systematic review and meta-analysis

IF 8.5 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2026-09-28 DOI:10.1038/s41531-026-01573-8

Jiang Wang, Hongshuai Zhou, Tian Tian, Jiayuan Wen, Yutong Wu, Jiahui Bian, Haotian Zhou, Yuchang Liang, Keqin Luo, Huixue Zuo, Zhixuan Zhou, Wenting Zhang, Zhiqi Jiang, Wenshu Chen, Maolin Zou, Jian Liao, Hao Zeng, Yibin Hu, Xiaotao Liang, Xin Jiang, Ziqian Guo, Xiaotong Sun, Muxin Hu, Jiacheng Zhang, Jiayi Zeng, Zuliang Gu, Xiaoming Zhang

{"title":"Cognitive impairment in Parkinson’s disease: prevalence and associations with cardiometabolic, vascular, and autonomic factors—a systematic review and meta-analysis","authors":"Jiang Wang, Hongshuai Zhou, Tian Tian, Jiayuan Wen, Yutong Wu, Jiahui Bian, Haotian Zhou, Yuchang Liang, Keqin Luo, Huixue Zuo, Zhixuan Zhou, Wenting Zhang, Zhiqi Jiang, Wenshu Chen, Maolin Zou, Jian Liao, Hao Zeng, Yibin Hu, Xiaotao Liang, Xin Jiang, Ziqian Guo, Xiaotong Sun, Muxin Hu, Jiacheng Zhang, Jiayi Zeng, Zuliang Gu, Xiaoming Zhang","doi":"10.1038/s41531-026-01573-8","DOIUrl":null,"url":null,"abstract":"Cognitive impairment is a common and disabling non-motor manifestation of Parkinson’s disease (PD), but its prevalence and associated factors remain unclear. This systematic review and meta-analysis aimed to estimate the pooled prevalence of cognitive impairment in PD and identify associated clinical factors. We searched electronic databases for observational studies and performed random-effects meta-analyses with subgroup analyses, sensitivity analyses, publication bias assessment, and GRADE evaluation. Fifty-five studies involving 103,145 participants were included. The pooled prevalence of cognitive impairment was 32.7% (95% CI: 27.1–38.7%), with substantial heterogeneity (I² = 97.7%). Prevalence varied according to diagnostic criteria and assessment tools. Orthostatic hypotension (OR = 2.18, 95% CI:1.71–2.77) and advanced age were strongly associated with cognitive impairment, while diabetes, hypertension, and metabolic syndrome showed additional associations. Evidence certainty ranged from low to very low. Cognitive impairment affects approximately one-third of individuals with PD, highlighting the need for early screening and longitudinal research.","PeriodicalId":19706,"journal":{"name":"NPJ Parkinson's Disease","volume":"23 1","pages":""},"PeriodicalIF":8.5000,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"NPJ Parkinson's Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41531-026-01573-8","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Cognitive impairment is a common and disabling non-motor manifestation of Parkinson’s disease (PD), but its prevalence and associated factors remain unclear. This systematic review and meta-analysis aimed to estimate the pooled prevalence of cognitive impairment in PD and identify associated clinical factors. We searched electronic databases for observational studies and performed random-effects meta-analyses with subgroup analyses, sensitivity analyses, publication bias assessment, and GRADE evaluation. Fifty-five studies involving 103,145 participants were included. The pooled prevalence of cognitive impairment was 32.7% (95% CI: 27.1–38.7%), with substantial heterogeneity (I² = 97.7%). Prevalence varied according to diagnostic criteria and assessment tools. Orthostatic hypotension (OR = 2.18, 95% CI:1.71–2.77) and advanced age were strongly associated with cognitive impairment, while diabetes, hypertension, and metabolic syndrome showed additional associations. Evidence certainty ranged from low to very low. Cognitive impairment affects approximately one-third of individuals with PD, highlighting the need for early screening and longitudinal research.

查看原文本刊更多论文

帕金森病的认知障碍：患病率及其与心脏代谢、血管和自主神经因素的关系——一项系统综述和荟萃分析

认知障碍是帕金森病（PD）常见的致残性非运动表现，但其患病率和相关因素尚不清楚。本系统综述和荟萃分析旨在估计PD患者认知功能障碍的总体患病率，并确定相关的临床因素。我们在电子数据库中检索观察性研究，并进行随机效应荟萃分析，包括亚组分析、敏感性分析、发表偏倚评估和GRADE评估。共纳入55项研究，涉及103,145名参与者。认知障碍的总患病率为32.7% (95% CI: 27.1-38.7%)，存在显著异质性（I²= 97.7%）。患病率因诊断标准和评估工具而异。直立性低血压（OR = 2.18, 95% CI: 1.71-2.77）和高龄与认知功能障碍密切相关，而糖尿病、高血压和代谢综合征则有额外的关联。证据确定性从低到非常低。大约三分之一的PD患者有认知障碍，这突出了早期筛查和纵向研究的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.