Alterations of subcortical structures are associated with anxiety in early Parkinson’s disease patients: a cross-sectional 7T MRI study

IF 8.5 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2026-10-03 DOI:10.1038/s41531-026-01532-3

Guillaume Carey, Michiel van Lier, Stijn Michielse, Amée F. Wolters, Kathy Dujardin, Mark L. Kuijf, Albert F. G. Leentjens

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引用次数: 0

Abstract

Anxiety is a prevalent non-motor symptom in Parkinson’s disease (PD), yet its neurobiological markers remain poorly understood. This study aimed to identify volumetric and morphological changes in subcortical structures associated with anxiety in early PD. In this cross-sectional study from the TRACK-PD cohort (Dutch Trial Register - NL7558), 105 non-demented PD patients (31 with anxiety [AnxPD], 74 without [nonAnxPD]) and 37 healthy controls (HC) underwent 7 T MRI. Subcortical regions including the amygdala, hippocampus, accumbens, caudate, putamen, and thalamus were segmented using FastSurfer. Shape analyses were performed via the Spherical Harmonics Point Distribution Model (SPHARM-PDM). Anxiety severity in PD was significantly associated with a bilateral reduction in caudate volume. Furthermore, AnxPD patients exhibited distinct shape deformations in the bilateral caudate, bilateral thalamus, left nucleus accumbens, and left amygdala compared to non-anxious patients. Significant shape differences in the left amygdala and left thalamus were also observed between AnxPD and HC groups. PD-related anxiety is linked to distinct structural remodeling of the striatum, thalamus, and amygdala. These morphometric changes represent potential imaging markers for the occurrence and progression of anxiety in early PD.

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皮层下结构的改变与早期帕金森病患者的焦虑有关：一项横断面7T MRI研究

焦虑是帕金森病（PD）中普遍存在的非运动症状，但其神经生物学标志物仍然知之甚少。本研究旨在确定早期PD患者与焦虑相关的皮质下结构的体积和形态学变化。在这项来自TRACK-PD队列（荷兰试验注册- NL7558）的横断面研究中，105名非痴呆性PD患者（31名患有焦虑症[AnxPD]， 74名没有焦虑症[nonAnxPD]）和37名健康对照（HC）接受了7次T MRI。使用FastSurfer对杏仁核、海马、伏隔核、尾状核、壳核和丘脑等皮质下区域进行分割。通过球面谐波点分布模型（spham - pdm）进行形状分析。PD患者的焦虑严重程度与双侧尾状核体积减少显著相关。此外，与非焦虑患者相比，AnxPD患者在双侧尾状核、双侧丘脑、左侧伏隔核和左侧杏仁核中表现出明显的形状变形。在AnxPD组和HC组之间，左杏仁核和左丘脑的形状也有显著差异。pd相关的焦虑与纹状体、丘脑和杏仁核的结构重塑有关。这些形态变化是早期PD患者焦虑发生和发展的潜在影像学标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.