An individual patient meta-analysis assessed the associations between change in albuminuria and acute changes in the glomerular filtration rate in randomized controlled trials of chronic kidney disease progression

IF 21.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2026-09-30 DOI:10.1016/j.kint.2026.08.030

Lesley A. Inker MD MS, Hiddo J.L. Heerspink PhD, Hocine Tighiouart MS, Shiyuan Miao MS, Juhi Chaudhari MPH, Lucia Del Vecchio MD, Jürgen Floege MD, Thierry Hannedouche MD PhD, Enyu Imai MD, Tazeen H. Jafar MBBS, Julia B. Lewis MD, Philip K.T. Li MD FRCP, Francesco Locatelli MD, Bart D. Maes PhD, Brendon L. Neuen MBBS PhD, Ronald D. Perrone MD, Francesco P. Schena MD, Robert D. Toto MD, Christoph Wanner MD, Tom Greene PhD

引用次数: 0

Abstract

Early changes in albuminuria and glomerular filtration rate (GFR) have been proposed as markers of treatment efficacy for individual patients. Here, we evaluated the relationship between changes in GFR and in albuminuria in the immediate period following initiation of medication across trials and within individual patients.

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在慢性肾脏疾病进展的随机对照试验中，个体患者荟萃分析评估了蛋白尿变化与肾小球滤过率急性变化之间的关系

蛋白尿和肾小球滤过率（GFR）的早期变化被认为是个体患者治疗效果的标志。在这里，我们评估了GFR变化和蛋白尿之间的关系，在试验和个体患者中，在开始用药后的一段时间内。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.