Dose–Response Relationship Between Physical Activity and Intrinsic Capacity Decline Among Hospitalised Older Patients

IF 1.8 4区医学 Q4 GERIATRICS & GERONTOLOGY

Australasian Journal on Ageing Pub Date : 2026-10-01 DOI:10.1111/ajag.70230

Wanting Fan, Qiuxia Qian, Lirong Huang, Zhenzhen Zhang, Huanhuan Wang, Tian Gao, Yidan Li, Ailing Yang, Yuxia Ma

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引用次数: 0

Abstract

Objective

Intrinsic capacity (IC) serves as the foundation for functional performance in older adults, and its decline exerts a significant negative impact on their overall health status. However, the dose–response relationship between physical activity (PA) and IC decline is unclear. The objective of this study was to examine the dose–response relationship between PA and IC decline in hospitalised older adults.

Methods

This cross-sectional study was conducted from August 2024 to July 2025, with hospitalised older patients recruited from three tertiary hospitals in Gansu Province, China. Data were collected using a general information questionnaire, the IC Assessment Scale and the International Physical Activity Questionnaire-Short Form (IPAQ-SF). Binary logistic regression and restricted cubic spline (RCS) models were used to explore the association between PA and IC decline, adjusting for potential confounders.

Results

The final analyses included a total of 534 hospitalised older patients. Using the low PA group as the reference, the moderate PA group was associated with a 66% lower likelihood of IC decline (OR = 0.34, 95% CI: 0.23–0.50), and the high PA group was associated with a 74% lower likelihood (OR = 0.26, 95% CI: 0.14–0.49). In the RCS analysis, a J-shaped nonlinear association was observed between PA levels and IC decline. Subgroup analyses by sex indicated that sex may serve as a potential moderator in the association between PA and IC decline.

Conclusions

This study revealed a J-shaped nonlinear association between PA and the likelihood of IC decline, with moderately higher PA levels associated with a lower likelihood of IC decline.

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住院老年患者体力活动与内在能力下降的剂量-反应关系

摘要内在容量（Intrinsic capacity， IC）是老年人功能表现的基础，其下降会对老年人整体健康状况产生显著的负面影响。然而，体力活动（PA）与IC下降之间的剂量-反应关系尚不清楚。本研究的目的是检查住院老年人PA和IC下降之间的剂量-反应关系。方法本横断面研究于2024年8月至2025年7月进行，从中国甘肃省三所三级医院招募住院老年患者。数据收集采用一般信息问卷、IC评估量表和国际体育活动问卷-简表（IPAQ-SF）。使用二元逻辑回归和限制三次样条（RCS）模型来探索PA和IC下降之间的关系，并对潜在的混杂因素进行了调整。结果最终分析共纳入534例住院老年患者。以低PA组为参照，中度PA组IC下降的可能性降低66% (OR = 0.34, 95% CI: 0.23-0.50)，高PA组IC下降的可能性降低74% （OR = 0.26, 95% CI: 0.14-0.49）。在RCS分析中，PA水平与IC下降呈j形非线性关联。按性别划分的亚组分析表明，性别可能在PA和IC下降之间的关联中起到潜在的调节作用。该研究揭示了PA与IC下降可能性之间的j型非线性关联，适度高的PA水平与IC下降的可能性较低相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australasian Journal on Ageing 医学-老年医学

CiteScore

3.10

自引率

6.20%

发文量

114

审稿时长

>12 weeks

期刊介绍： Australasian Journal on Ageing is a peer reviewed journal, which publishes original work in any area of gerontology and geriatric medicine. It welcomes international submissions, particularly from authors in the Asia Pacific region.