Changes in Serum Aspartate Aminotransferase in Patients with Acute Myocardial Infarction.

Abstract

Acute myocardial infarction (AMI), more commonly known as heart attack is a medical emergency and the leading cause of death for both men and women all over the world. There is a correlation between changes in the serum aspartate aminotransferase with acute myocardial infarction. This study was undertaken to evaluate the changes in serum aspartate aminotransferase status in patients with acute myocardial infarction. This cross-sectional study was carried out in the Department of Biochemistry, Mymensingh Medical College, Bangladesh with the collaboration of the Department of Cardiology, Mymensingh Medical College Hospital, Mymensingh, during the period of July 2021 to June 2022. A total of 100 subjects were included in this study among them, 50 were diagnosed AMI patients denoted as case group and 50 were normal healthy individuals denoted as control group. Serum aspartate aminotransferase was determined by colorimetric method by using electrolyte analyzer for each sample. All statistical analysis was done by using SPSS (statistical package for social science) windows package version 26.0. P value <0.05 was considered significant. The mean±SD values of serum aspartate aminotransferase were 76.28±12.87 U/L and 22.58±6.24 U/L in case group and control group respectively. The analysis showed that there was highly significant increase in mean serum aspartate aminotransferase levels between two groups. This was a cross-sectional study. Analyzing the findings of the present study, highly significant increase in serum aspartate aminotransferase level was observed in AMI patients. A large-scale prospective study with the application of more sophisticated technology may be planned to find out the relationship of this biochemical variable with AMI.