Association between restless legs syndrome and erectile dysfunction: a systematic review and meta-analysis.

IF 2 4区医学 Q4 CLINICAL NEUROLOGY

Sleep and Biological Rhythms Pub Date : 2026-07-20 eCollection Date: 2026-10-01 DOI:10.1007/s41105-026-00674-4

Rafael Matos Vieira Gordilho, Nilo Jorge Carvalho Leão Barreto, Felipe Pinho E Albuquerque Silva, João Victor Pereira Gonzalez, Nathalia Pedreira Santos de Lemos, Kenzo Ogasawara Donato, Paula Alana Morais Seixas, Gabriela Nunes E Brito, Henrique Brasileiro Terceiro, Felipe Pereira Garrido Pazos, Rodrigo Barbosa Freire Silvão, Cristina Salles

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引用次数: 0

Abstract

Objective: To evaluate whether patients with RLS have increased odds of ED compared with non-RLS controls.

Methods: We conducted a systematic review and meta-analysis analyzing the odds of ED in patients with RLS. We included studies that: (i) evaluated adults with a diagnosis of RLS established by the pre-established criteria; (ii) included a control group without RLS; and (iii) evaluated outcomes related to the odds of ED in patients with RLS. We followed the PRISMA 2020 protocol.

Results: This systematic review included a total sample of 33,740 participants. Patients with RLS had 70% higher odds of ED compared with non-RLS controls (OR = 1.70; 95% CI: 1.52-1.91; p < 0.001; I² = 0%). The group with severe RLS had lower odds of ED than the mild-moderate RLS group (OR = 0.67; 95% CI: 0.53-0.84; p = 0.0005). The RLS group presented increased odds of severe ED compared with non-RLS controls (OR = 4.51; 95% CI: 1.52-13.33; p = 0.006; I² = 0%), but no significant difference compared with controls for mild or moderate ED (p > 0.05).

Conclusion: Individuals with RLS have 70% higher odds of ED compared with non-RLS controls. Severe ED was more frequent among patients with RLS, while no significant differences were observed for mild or moderate ED. These findings support ED screening in patients with RLS.

Supplementary information: The online version contains supplementary material available at https://doi.org/10.1007/s41105-026-00674-4.

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不宁腿综合征与勃起功能障碍之间的关系：系统回顾和荟萃分析。

目的：评价与非RLS患者相比，RLS患者发生ED的几率是否增加。方法：我们进行了一项系统综述和荟萃分析，分析了RLS患者发生ED的几率。我们纳入了以下研究：(i)评估了根据预先制定的标准诊断为RLS的成年人；（ii）纳入无RLS的对照组；（iii）评估与RLS患者ED发生率相关的结果。我们遵循PRISMA 2020协议。结果：本系统综述共纳入33,740名参与者。与非RLS对照组相比，RLS患者发生ED的几率高出70% （OR = 1.70; 95% CI: 1.52-1.91; p = 0.0005）。与非RLS对照组相比，RLS组出现严重ED的几率增加（OR = 4.51; 95% CI: 1.52-13.33; p = 0.006; I²= 0%），但轻度或中度ED与对照组相比无显著差异（p < 0.05）。结论：与非RLS对照组相比，RLS患者ED发生率高70%。重度ED在RLS患者中更为常见，而轻度ED和中度ED的发生率无显著差异。这些发现支持对RLS患者进行ED筛查。补充信息：在线版本包含补充资料，可在https://doi.org/10.1007/s41105-026-00674-4上获得。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep and Biological Rhythms 医学-临床神经学

CiteScore

2.20

自引率

9.10%

发文量

审稿时长

>12 weeks

期刊介绍： Sleep and Biological Rhythms is a quarterly peer-reviewed publication dealing with medical treatments relating to sleep. The journal publishies original articles, short papers, commentaries and the occasional reviews. In scope the journal covers mechanisms of sleep and wakefullness from the ranging perspectives of basic science, medicine, dentistry, pharmacology, psychology, engineering, public health and related branches of the social sciences