Defining pathogenic macrophages in the fibrotic niche of human chronic liver disease

IF 25.5 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2026-09-29 DOI:10.1038/s41588-026-02778-6

引用次数: 0

Abstract

Monocyte-derived macrophages are central in liver fibrosis pathogenesis, but the specific phenotype of the pro-fibrotic subpopulation is unknown. Using a liver single-cell atlas from 77 patients with chronic liver disease, we resolve 2 subpopulations of TREM2+ scar-associated macrophages and identify OLR1 as a candidate therapeutic target to selectively modulate pro-fibrotic macrophage functions and thereby attenuate liver fibrosis.

查看原文本刊更多论文

确定人类慢性肝病纤维化生态位中的致病性巨噬细胞。

单核细胞来源的巨噬细胞在肝纤维化发病机制中起中心作用，但促纤维化亚群的具体表型尚不清楚。利用77例慢性肝病患者的肝脏单细胞图谱，研究人员分析了TREM2+疤痕相关巨噬细胞的2个亚群，并确定了OLR1作为选择性调节促纤维化巨噬细胞功能的候选治疗靶点，从而减轻肝纤维化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution