{"title":"Rapid intracystic growth of spindle cell-type anaplastic carcinoma derived from intraductal papillary mucinous carcinoma.","authors":"Reiko Yamada, Ayako Okuda, Shoma Sawai, Minako Urata, Yasuaki Shimada, Kenji Nose, Toji Murbayashi, Hayato Nakagawa","doi":"10.1007/s12328-026-02457-3","DOIUrl":null,"url":null,"abstract":"<p><p>Anaplastic carcinoma of the pancreas (ACP) is a rare and aggressive malignancy. We report a case of spindle cell-type ACP arising from intraductal papillary mucinous carcinoma (IPMC) showing rapid intra-cystic growth. A 73 year-old man was incidentally found to have a pancreatic cyst, initially diagnosed as a simple cyst. After 18 months, a solid component appeared within the cyst and rapidly enlarged within one month. Distal pancreatectomy was performed. Histopathology revealed spindle cell-type anaplastic carcinoma arising from invasive IPMC. Despite aggressive histology, curative resection was achieved. The patient remains recurrence-free for 50 months. Rapid changes in pancreatic cysts warrant careful evaluation and timely surgical intervention.</p>","PeriodicalId":10364,"journal":{"name":"Clinical Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Journal of Gastroenterology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12328-026-02457-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Anaplastic carcinoma of the pancreas (ACP) is a rare and aggressive malignancy. We report a case of spindle cell-type ACP arising from intraductal papillary mucinous carcinoma (IPMC) showing rapid intra-cystic growth. A 73 year-old man was incidentally found to have a pancreatic cyst, initially diagnosed as a simple cyst. After 18 months, a solid component appeared within the cyst and rapidly enlarged within one month. Distal pancreatectomy was performed. Histopathology revealed spindle cell-type anaplastic carcinoma arising from invasive IPMC. Despite aggressive histology, curative resection was achieved. The patient remains recurrence-free for 50 months. Rapid changes in pancreatic cysts warrant careful evaluation and timely surgical intervention.
期刊介绍：
The journal publishes Case Reports and Clinical Reviews on all aspects of the digestive tract, liver, biliary tract, and pancreas. Critical Case Reports that show originality or have educational implications for diagnosis and treatment are especially encouraged for submission. Personal reviews of clinical gastroenterology are also welcomed. The journal aims for quick publication of such critical Case Reports and Clinical Reviews.
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