Association of Sarcopenia With Global, Motor, Cognitive, and Swallowing Function Prognosis in Stroke Patients: A Systematic Review and Meta-Analysis

IF 2.8 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2026-09-29 DOI:10.1002/brb3.71810

Dandan Xie, Mingming Ma, Lu Chen

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引用次数: 0

Abstract

Objective

Sarcopenia has been demonstrated to correlate with the prognosis of stroke. This study aimed to systematically evaluate the impact of sarcopenia on global, motor, cognitive, and swallowing function outcomes in stroke patients.

Methods

Relevant studies investigating the association between sarcopenia and multidimensional prognostic outcomes in stroke were retrieved from the PubMed, Embase, Web of Science, Cochrane Library, and Scopus databases. The primary outcome was the risk of poor global functional prognosis assessed by the modified Rankin Scale (mRS). Secondary outcomes included motor function scores (Functional Independence Measure-motor, FIM-motor), cognitive function scores, and the risk of swallowing dysfunction.

Results

A total of 36 cohort studies were finally included. Pooled results indicated that stroke patients with comorbid sarcopenia faced a notably elevated risk of poor global functional prognosis (mRS, OR = 2.43, 95% CI: 1.95 to 3.03, p < 0.001). The motor function scores (FIM-motor, SMD = −0.94, 95% CI: −1.11 to −0.77, p < 0.001) and cognitive function scores (FIM-cognition or Montreal Cognitive Assessment, SMD = −0.95, 95% CI: −1.22 to −0.69, p < 0.001) in the sarcopenia group were significantly lower than those in the non-sarcopenia group, while the risk of swallowing dysfunction showed a notable but non-significant elevation (endotracheal intubation or Functional Oral Intake Scale, OR = 1.45, 95% CI: 0.94 to 2.25, p = 0.09). Subgroup analyses indicated that the patient populations, cut-off value of mRS, follow-up duration, stroke type, and diagnostic criteria for sarcopenia were the main sources of heterogeneity. Sensitivity analyses confirmed the robustness of the results. Egger's test suggested the presence of publication bias, but the conclusions remained valid after correction using the trim-and-fill method.

Conclusion

Sarcopenia is an important risk factor for poor global, motor, cognitive, and swallowing function prognosis in stroke patients. In clinical practice, sarcopenia screening should be incorporated into the routine assessment of stroke patients, and individualized interventions should be promptly implemented for high-risk populations to improve long-term prognosis.

查看原文本刊更多论文

脑卒中患者肌肉减少症与全身、运动、认知和吞咽功能预后的关系：一项系统综述和荟萃分析。

目的：肌少症与脑卒中预后相关。本研究旨在系统评估肌肉减少症对脑卒中患者整体、运动、认知和吞咽功能结局的影响。方法：从PubMed、Embase、Web of Science、Cochrane Library和Scopus数据库中检索研究肌肉减少症与卒中多维预后之间关系的相关研究。主要终点是通过改良的Rankin量表（mRS）评估整体功能预后不良的风险。次要结果包括运动功能评分（功能独立测量-运动，fim -运动），认知功能评分和吞咽功能障碍的风险。结果：共纳入36项队列研究。综合结果显示，卒中合并肌减少症患者整体功能预后不良的风险显著升高（mRS, OR = 2.43, 95% CI: 1.95 ~ 3.03, p < 0.001）。运动功能评分(FIM-motor SMD = -0.94, 95% CI: -1.11 ~ -0.77, p < 0.001)和认知功能评分(FIM-cognition或蒙特利尔认知评估、SMD = -0.95, 95% CI: -1.22 ~ -0.69, p < 0.001) sarcopenia组明显低于non-sarcopenia组,而吞咽功能障碍的风险表现出明显的但非重大的海拔(气管插管或功能口服摄入比例,或= 1.45,95% CI: 0.94 ~ 2.25, p = 0.09)。亚组分析表明，患者群体、mRS的临界值、随访时间、卒中类型和肌少症的诊断标准是异质性的主要来源。敏感性分析证实了结果的稳健性。Egger的检验表明存在发表偏倚，但使用修剪填充法校正后结论仍然有效。结论：肌少症是脑卒中患者整体功能、运动功能、认知功能和吞咽功能预后不良的重要危险因素。在临床实践中，应将肌少症筛查纳入脑卒中患者的常规评估，并对高危人群及时实施个体化干预，以改善远期预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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