The C-Reactive Protein–Triglyceride–Glucose Index and Functional Outcomes in Acute Ischemic Stroke Patients Following Endovascular Thrombectomy

IF 2.8 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2026-09-29 DOI:10.1002/brb3.71770

Jing Bian, Junfeng Xu, Xiuyun Li, Xianhui Ding, Yapeng Guo, Ke Yang, Xianjun Huang, Shoucai Zhao, Zhiming Zhou, Zibao Li

{"title":"The C-Reactive Protein–Triglyceride–Glucose Index and Functional Outcomes in Acute Ischemic Stroke Patients Following Endovascular Thrombectomy","authors":"Jing Bian, Junfeng Xu, Xiuyun Li, Xianhui Ding, Yapeng Guo, Ke Yang, Xianjun Huang, Shoucai Zhao, Zhiming Zhou, Zibao Li","doi":"10.1002/brb3.71770","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background and Purpose</h3>\n \n <p>The C-reactive protein–triglyceride–glucose index (CTI), capturing insulin resistance (IR) and systemic inflammation, is related to stroke prognosis in general, but has not yet been studied with respect to functional outcomes after endovascular thrombectomy (EVT).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A retrospective analysis was carried out on individuals with acute ischemic stroke (AIS) experiencing EVT (September 2018–December 2024). CTI is measured as: 0.412 × Ln (C-reactive protein) (mg/L) + Ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)]/2. The endpoint was unfavorable functional outcomes, characterized by a modified Rankin Scale (mRS) score of 3–6 at 90-day follow-up. Restricted cubic splines (RCS) and logistic regression (LR) analysis were utilized to estimate the link between the CTI and clinical outcomes.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Among 813 patients, a high CTI level was significantly correlated with unfavorable functional outcome (<i>p</i> < 0.05). Compared with patients in the lowest quartile (Q1) of CTI, those in the highest CTI quartile (Q4) demonstrated an increased likelihood of unfavorable outcome (adjusted odds ratio [aOR] of 2.04, 95% confidence interval (95% CI) of 1.17–3.54). RCS modeling, after adjustment for significant variables identified in the univariate analysis, confirmed that there was no nonlinear connection between CTI levels and the probability of unfavorable functional recovery. Stratified analysis indicated that these associations were more significant among elderly and non-smoking patients.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The CTI is an independent indicator of functional outcomes in individuals with AIS undergoing EVT, underlining its potential clinical value as a readily accessible marker for risk stratification and individualized prognostic assessment.</p>\n </section>\n </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 10","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624537/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain and Behavior","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/brb3.71770","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background and Purpose

The C-reactive protein–triglyceride–glucose index (CTI), capturing insulin resistance (IR) and systemic inflammation, is related to stroke prognosis in general, but has not yet been studied with respect to functional outcomes after endovascular thrombectomy (EVT).

Methods

A retrospective analysis was carried out on individuals with acute ischemic stroke (AIS) experiencing EVT (September 2018–December 2024). CTI is measured as: 0.412 × Ln (C-reactive protein) (mg/L) + Ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)]/2. The endpoint was unfavorable functional outcomes, characterized by a modified Rankin Scale (mRS) score of 3–6 at 90-day follow-up. Restricted cubic splines (RCS) and logistic regression (LR) analysis were utilized to estimate the link between the CTI and clinical outcomes.

Results

Among 813 patients, a high CTI level was significantly correlated with unfavorable functional outcome (p < 0.05). Compared with patients in the lowest quartile (Q1) of CTI, those in the highest CTI quartile (Q4) demonstrated an increased likelihood of unfavorable outcome (adjusted odds ratio [aOR] of 2.04, 95% confidence interval (95% CI) of 1.17–3.54). RCS modeling, after adjustment for significant variables identified in the univariate analysis, confirmed that there was no nonlinear connection between CTI levels and the probability of unfavorable functional recovery. Stratified analysis indicated that these associations were more significant among elderly and non-smoking patients.

Conclusion

The CTI is an independent indicator of functional outcomes in individuals with AIS undergoing EVT, underlining its potential clinical value as a readily accessible marker for risk stratification and individualized prognostic assessment.

查看原文本刊更多论文

急性缺血性卒中患者血管内取栓后c反应蛋白-甘油三酯-葡萄糖指数和功能结局

背景和目的：c反应蛋白-甘油三酯-葡萄糖指数（CTI），反映胰岛素抵抗（IR）和全身炎症，通常与脑卒中预后有关，但尚未研究血管内血栓切除术（EVT）后的功能结局。方法：回顾性分析2018年9月- 2024年12月急性缺血性脑卒中（AIS） EVT患者。CTI的测量值为：0.412 × Ln （c反应蛋白）(mg/L) + Ln[空腹甘油三酯（mg/dL） ×空腹葡萄糖（mg/dL）]/2。终点是不良的功能结局，在90天的随访中，修改的Rankin量表（mRS）评分为3-6分。使用限制性三次样条（RCS）和逻辑回归（LR）分析来估计CTI与临床结果之间的联系。结果：813例患者中高CTI水平与不良功能预后显著相关（p < 0.05）。与CTI最低四分位数（Q1）的患者相比，CTI最高四分位数（Q4）的患者出现不良结果的可能性增加（调整优势比[aOR]为2.04,95%可信区间（95% CI）为1.17-3.54）。在调整单变量分析中确定的重要变量后，RCS建模证实CTI水平与不利功能恢复的概率之间没有非线性联系。分层分析表明，这些关联在老年人和非吸烟患者中更为显著。结论：CTI是评估接受EVT的AIS患者功能结局的独立指标，强调了其作为风险分层和个性化预后评估指标的潜在临床价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

期刊介绍： Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)