Real-World Experience of Risankizumab in Refractory Pediatric Inflammatory Bowel Disease.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2026-09-29 eCollection Date: 2026-10-01 DOI:10.14309/crj.0000000000002316

Ali Alsarhan, Balaji Krishnamurthy, Eman Elyyan, Mohammad Alhajjar, Christos Tzivinikos

引用次数: 0

Abstract

The incidence of pediatric inflammatory bowel disease (IBD) is rising globally. Anti-tumor necrosis factor agents remain the mainstay of treatment, but a significant number of patients experience treatment failure. This case-series presents real-world experience using risankizumab, an IL-23 inhibitor, in 9 children with severe-refractory IBD. Multiple biologics had failed in all patients before initiation. Response was assessed using symptoms, biomarkers, endoscopy, and imaging. Five patients achieved clinical remission, and 4 failed to achieve complete remission. Noninvasive monitoring tools, such as intestinal ultrasound, were used. No adverse events were reported. Risankizumab may be a promising option in refractory pediatric IBD.

查看原文本刊更多论文

利桑单抗治疗难治性儿童炎症性肠病的现实经验

全球儿童炎症性肠病（IBD）的发病率正在上升。抗肿瘤坏死因子药物仍然是主要的治疗方法，但相当多的患者经历治疗失败。本病例系列展示了使用IL-23抑制剂risankizumab治疗9例严重难治性IBD患儿的真实经验。在开始治疗前，多种生物制剂在所有患者中均失败。使用症状、生物标志物、内窥镜检查和影像学评估反应。5例患者达到临床缓解，4例未达到完全缓解。使用无创监测工具，如肠道超声。无不良事件报告。Risankizumab可能是难治性儿童IBD的一个有希望的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.