An Effective Electrosynthesis of Catalytic Active Nanocomposites of Silver and Palladium Nanoparticles with Porphyrins, Having an Ability to Bind Antitumor Drugs

IF 5.6 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2026-08-28 DOI:10.1007/s11468-026-03451-8

Rezeda R. Fazleeva, Gulnaz R. Nasretdinova, Andrey A. Maslennikov, Irek R. Nizameev, Igor V. Yanilkin, Nina V. Biktanova, Aidar T. Gubaidullin, Albina Y. Ziganshina, Vitaliy V. Yanilkin

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Abstract

Effective porphyrin-mediated electrosyntheses of nanocomposites of silver and palladium nanoparticles (AgNPs and PdNPs) with tetraphenylporphyrin (TPP), as well as its complex with cobalt(II) (TPPCo(II)) were carried out in the absence and presence of a stabilizer poly(N-vinylpyrrolidone) (PVP), in dimethylsulfoxide (DMSO) medium at room temperature. Silver or palladium ions were in situ generated directly during electrolysis by dissolving the corresponding metal anodes. The synthesis results were universal hybrid organo-inorganic nanocomposites of mainly spherical AgNPs and PdNPs, stabilized by the coordination interaction of pyrrole nitrogen atoms with metal(0) in the porphyrin matrix or by polymer PVP The X-ray photoelectron spectroscopy (XPS) of obtained samples also confirms a presence of metallic palladium as nanocomposite with porphyrin. The fluorescence spectroscopy study of the obtained nanocomposites ability to bind the antitumor drug doxorubicin (DOX) demonstrated the presence of almost 100% quenching of DOX fluorescence in the presence of all nanocomposites with palladium and 71% quenching in the presence of the Ag/TPPCo(II)@PVP composite. A study of the nanocomposites catalytic activity in the test reaction of p-nitrophenol (pNPh) reduction with sodium borohydride showed that all the studied nanocomposites had a catalytic activity comparable and even prevailing relative to the previously obtained results.

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具有结合抗肿瘤药物能力的卟啉纳米银和钯纳米复合材料的有效电合成

在没有稳定剂聚（n-乙烯基吡咯烷酮）（PVP）存在的情况下，在二甲基亚砜（DMSO）介质中，在室温下，卟啉介导的银和钯纳米复合材料（AgNPs和PdNPs）与四苯基卟啉（TPP）及其与钴（II）的配合物（TPPCo(II)）的有效电合成。在电解过程中，通过溶解相应的金属阳极直接在原位生成银或钯离子。结果表明，合成的AgNPs和PdNPs主要由球形的AgNPs和PdNPs组成，通过吡咯氮原子与卟啉基体中的金属(0)或聚合物PVP的配位相互作用来稳定。所得样品的x射线光电子能谱（XPS）也证实了金属钯作为卟啉纳米复合材料的存在。对纳米复合材料与抗肿瘤药物阿霉素（DOX）结合能力的荧光光谱研究表明，在所有纳米复合材料与钯的存在下，DOX荧光几乎100%猝灭，而在Ag/TPPCo(II)@PVP复合材料存在下，DOX荧光猝灭71%。对纳米复合材料与硼氢化钠还原对硝基苯酚（pNPh）反应的催化活性进行了研究，结果表明，所研究的纳米复合材料的催化活性与已有的结果相当，甚至具有优势。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.