Advanced Design of Kretschmann Based SPR Biosensor, Combining Cu Nanolayer, Perovskite Oxides and 2D-Nanomaterials for Ultrasensitive Detection

IF 5.6 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL
Fatima Houari, Mohamed El barghouti, Abdellah Mir, Abdellatif Akjouj
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Abstract

In this research, we report on the analysis and optimization of the detection performance of an original nanodesign for a surface plasmon resonance (SPR) sensor, with a view to several applications in the fields of processing and diagnostics. Our enhanced SPR nanodesign is built on a Kretschmann hybrid configuration, consisting of a BK7 prism, a Cu film interleaved with a WO\(_{3}\) layer, and covered with a hybrid multilayer of perovskite oxide combined with a monolayer of graphene or black phosphorus, as well as the sensing medium. The finite element method (FEM), associated with an excitation at 633 nm, is used to analyze the plasmonic properties of the nanodesign. We analyze performance parameters such as detection sensitivity, sensitivity enhancement, figure of merit (FoM), and electric field distribution. Firstly, the study focuses on optimizing the effect of different layers of nanomaterials and their thicknesses on surface plasmon resonance and SPR biosensor performance. A detection sensitivity of around 576 deg/RIU and a FoM of 175.07 RIU\(^{-1}\) were found. These performance values are enhanced by 500% and 13.06% respectively, relative to those of a conventional SPR sensor (BK7/WO\(_{3}\)/Cu/SM). Subsequently, we modeled the SPR biosensor optimized in this work to show how plasmon resonance and detection performance are affected by the refractive index of infected and normal blood samples containing plasma. The current SPR design can be used in highly sensitive biomedical and environmental detection and diagnostic applications.

基于Kretschmann的SPR生物传感器的先进设计,结合Cu纳米层,钙钛矿氧化物和2d纳米材料用于超灵敏检测
在这项研究中,我们报告了一种原始纳米设计的表面等离子体共振(SPR)传感器的检测性能的分析和优化,以期在加工和诊断领域的几个应用。我们的增强型SPR纳米设计基于Kretschmann杂化结构,由BK7棱镜、与WO \(_{3}\)层交错的Cu膜、覆盖有混合多层钙钛矿氧化物(结合单层石墨烯或黑磷)以及传感介质组成。采用有限元法(FEM),结合633 nm激发,分析了纳米设计的等离子体特性。我们分析了检测灵敏度、灵敏度增强、优值图(FoM)和电场分布等性能参数。首先,研究了不同纳米材料层数及其厚度对表面等离子体共振和SPR生物传感器性能的影响。检测灵敏度约为576度/RIU, FoM为175.07 RIU \(^{-1}\)。这些性能值提高了500% and 13.06% respectively, relative to those of a conventional SPR sensor (BK7/WO\(_{3}\)/Cu/SM). Subsequently, we modeled the SPR biosensor optimized in this work to show how plasmon resonance and detection performance are affected by the refractive index of infected and normal blood samples containing plasma. The current SPR design can be used in highly sensitive biomedical and environmental detection and diagnostic applications.
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来源期刊
Plasmonics
Plasmonics 工程技术-材料科学:综合
CiteScore
5.90
自引率
6.70%
发文量
164
审稿时长
2.1 months
期刊介绍: Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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