Palladium/copper-catalyzed 1,2-arylboration of styrenes with b2pin2 and indoles

Abstract

Boryldifunctionalization of alkenes has emerged as a valuable synthetic tool for constructing complex organoboron compounds. While significant advances have been achieved in carboboration reactions with B₂pin₂ and organohalides, the boryldifunctionalization of simple alkenes with nucleophiles remains relatively underdeveloped. Herein, we report a novel approach for 1,2-arylboration of styrenes using a palladium/copper catalytic system. This protocol enables a three-component coupling of readily available styrenes, B₂pin₂, and structurally diverse indoles through C–H functionalization, delivering 2-boryl-1,1-diarylalkanes in moderate to good yields.