Quorum sensing molecules enhance cadmium detoxification and cellular removal in the marine diatom Phaeodactylum tricornutum.

IF 4.7 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

World journal of microbiology & biotechnology Pub Date : 2026-09-28 DOI:10.1007/s11274-026-05294-1

Qingnan Yu, Siting Wang, Mengxuan Chang, Jiale Chen, Menglei Ye, Xinyu Pei, Yanping Wei, Chunhua Zhang, Ying Ge

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引用次数: 0

Abstract

Acyl-homoserine lactones (AHLs) are ubiquitous bacteria-derived quorum-sensing molecules in marine environments and play important roles in regulating microbial physiological processes. However, their influence on metal detoxification and handling in microalgae remains poorly understood. Here, we investigated the effects of exogenous AHLs on cell growth, metabolic responses, and cadmium (Cd) removal in the marine diatom Phaeodactylum tricornutum under both Cd-free and Cd-contaminated conditions. It was demonstrated that AHLs slightly inhibited the growth of P. tricornutum and increased extracellular polymeric substances (EPS) production under Cd-free conditions. Under Cd exposure, AHLs significantly suppressed growth and enhanced oxidative stress responses, as indicated by increased activities of superoxide dismutase (SOD) and elevated levels of malondialdehyde (MDA) and glutathione (GSH). Besides, AHLs increased the Cd removal per cell of P. tricornutum, reaching 1.15-2.12 times that of the control. These results demonstrate that quorum sensing molecules can regulate detoxification-related metabolic responses and enhance cellular Cd handling in microalgae, providing new insights into microbe-mediated metal detoxification and highlighting the potential relevance of quorum sensing in microalgae-based biotechnological applications.

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群体感应分子增强了海洋硅藻中镉的解毒和细胞去除。

酰基高丝氨酸内酯（AHLs）是海洋环境中普遍存在的细菌群体感应分子，在调节微生物生理过程中发挥重要作用。然而，它们对微藻中金属解毒和处理的影响仍然知之甚少。在此，我们研究了外源AHLs对海洋硅藻三角藻（Phaeodactylum tricornutum）在无Cd和Cd污染条件下细胞生长、代谢反应和镉（Cd）去除的影响。结果表明，在无cd条件下，AHLs能轻微抑制三角三角霉的生长，增加胞外聚合物（EPS）的产生。在Cd暴露下，AHLs显著抑制生长并增强氧化应激反应，其表现为超氧化物歧化酶（SOD）活性升高、丙二醛（MDA）和谷胱甘肽（GSH）水平升高。此外，AHLs提高了三角角藻细胞对Cd的去除率，达到对照的1.15 ~ 2.12倍。这些结果表明，群体感应分子可以调节与解毒相关的代谢反应，增强微藻细胞对Cd的处理，为微生物介导的金属解毒提供了新的见解，并突出了群体感应在微藻生物技术应用中的潜在相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World journal of microbiology & biotechnology 工程技术-生物工程与应用微生物

CiteScore

6.30

自引率

2.40%

发文量

257

审稿时长

2.5 months

期刊介绍： World Journal of Microbiology and Biotechnology publishes research papers and review articles on all aspects of Microbiology and Microbial Biotechnology. Since its foundation, the Journal has provided a forum for research work directed toward finding microbiological and biotechnological solutions to global problems. As many of these problems, including crop productivity, public health and waste management, have major impacts in the developing world, the Journal especially reports on advances for and from developing regions. Some topics are not within the scope of the Journal. Please do not submit your manuscript if it falls into one of the following categories: · Virology · Simple isolation of microbes from local sources · Simple descriptions of an environment or reports on a procedure · Veterinary, agricultural and clinical topics in which the main focus is not on a microorganism · Data reporting on host response to microbes · Optimization of a procedure · Description of the biological effects of not fully identified compounds or undefined extracts of natural origin · Data on not fully purified enzymes or procedures in which they are applied All articles published in the Journal are independently refereed.