What the ‘negative space’ tells us about the immunology of multiple sclerosis

IF 47.1 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2026-09-28 DOI:10.1038/s41577-026-01358-3

Max Kaufmann, Ralf Gold, Lars Fugger

引用次数: 0

Abstract

Multiple sclerosis is defined as much by what remains unknown as by what is known. By examining five persistent ‘negative spaces’ in the field, we argue that its pathogenesis stems from several, dynamic interactions that affect immunity, infection and tissue resilience rather than from a single missing cause. By exploring five enduring “negative spaces” in multiple sclerosis (MS) research, Kaufmann, Gold and Fugger challenge simple explanations of disease pathogenesis. Their Comment argues that MS emerges from complex interactions between immunity, infection and tissue resilience, offering a fresh framework for understanding progression and therapeutic intervention.

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“负空间”告诉我们多发性硬化症的免疫学。

多发性硬化症的定义，既取决于已知，也取决于未知。通过研究该领域五个持续存在的“负空间”，我们认为其发病机制源于影响免疫、感染和组织弹性的几个动态相互作用，而不是单一的缺失原因。通过探索多发性硬化症（MS）研究中五个长期存在的“负面空间”，考夫曼、戈尔德和富格尔挑战了对疾病发病机制的简单解释。他们的评论认为，MS是免疫、感染和组织弹性之间复杂的相互作用产生的，为理解进展和治疗干预提供了一个新的框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.