A dual-action biotin nanogel for accelerated wound healing: a bioinspired approach to antioxidant and regenerative delivery.

IF 1.6 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2026-09-29 DOI:10.1080/10286020.2026.2736040

Samaa Abdullah, Samar Thiab, Alaa A Al-Masud, Sami H Alonazi, Hatim S AlKhatib, Imad Hamadneh

引用次数: 0

Abstract

A biotin-coenzyme Q10-sodium alginate (BTN-CoQ10-SA) nanogel was developed for topical wound healing through combined antioxidant and regenerative delivery. The optimized nanogel showed a particle size of ∼115 nm, zeta potential of -35.1 mV, encapsulation efficiency of 88.3%, and sustained BTN release over 24 h. In a rat excisional wound model, the nanogel achieved 95.1% wound closure by day 14 and significantly outperformed the untreated control. Treatment also increased VEGF, collagen I, and TGF-β1 expression while reducing IL-6 levels. These findings demonstrate the potential of BTN-CoQ10-SA nanogels as a sustained topical system for promoting wound repair.

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用于加速伤口愈合的双作用生物素纳米凝胶：一种生物启发的抗氧化和再生递送方法。

一种生物素辅酶q10 -海藻酸钠（BTN-CoQ10-SA）纳米凝胶通过联合抗氧化和再生递送用于局部伤口愈合。优化后的纳米凝胶粒径为~ 115 nm， zeta电位为-35.1 mV，包封效率为88.3%，BTN持续释放超过24 h。在大鼠切除伤口模型中，纳米凝胶在第14天达到95.1%的伤口愈合，明显优于未治疗的对照组。治疗还增加了VEGF、胶原I和TGF-β1的表达，同时降低了IL-6的水平。这些发现证明了BTN-CoQ10-SA纳米凝胶作为促进伤口修复的持续局部系统的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.