Two new C₁₅-nupharidines from the rhizomes of Nuphar pumila.

IF 1.6 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2026-09-28 DOI:10.1080/10286020.2026.2738699

Xue-Li Zhi, Sheng-Dan Mi, Ying Li, Yan Huang, Jiang Li, Guo-Dong Yao, Guo-Zhu Su, Yong Li

引用次数: 0

Abstract

Two new C₁₅-nupharidines compounds (1, 2), named (-)-nuphamic acid and (-)-nuphamine-11-O-β-_D-glucopyranoside, together with two known analogues (3, 4), were isolated from the rhizomes of Nuphar pumila. Their structures were determined by analysis of spectroscopic data, including HRESIMS, 1D and 2D NMR, as well as calculated and experimental ECD data. In vitro evaluation of protein tyrosine phosphatase-1B (PTP1B) activity revealed that compound 1 inhibited the enzyme with an IC₅₀ value of 25.6 ± 7.6 μM.

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牛蒡根状茎中两个新的c15 -nupharidine。

从芦笋根状茎中分离到两个新的c15 - nuphinines化合物（1,2），分别命名为(-)- nuphaic acid和(-)- nuphaamine -11- o -β- d -glucopyranoside，以及两个已知的类似物（3,4）。通过分析光谱数据，包括hresms， 1D和2D NMR，以及计算和实验ECD数据来确定它们的结构。体外测定蛋白酪氨酸磷酸酶- 1b （PTP1B）活性发现，化合物1对该酶的抑制IC50值为25.6±7.6 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.

Two new C15-nupharidines from the rhizomes of Nuphar pumila.

Abstract

Two new C₁₅-nupharidines from the rhizomes of Nuphar pumila.