Additive and Dose-Dependent Effects of Coenzyme Q10 Combined With Myoinositol on Insulin Resistance and Hyperandrogenism in Women With Polycystic Ovary Syndrome: A Retrospective Controlled Study

IF 1.7 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2026-09-28 DOI:10.1111/jog.70502

Burcu Dincgez, Gulten Ozgen, Nergis Kender Erturk, Hazel Cagın Kuzey, Esra Kartal Golcuk

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引用次数: 0

Abstract

Aim

Polycystic ovary syndrome (PCOS) is characterized by insulin resistance, hyperandrogenism, and reproductive dysfunction. Myoinositol and coenzyme Q10 (CoQ10) have complementary metabolic and hormonal effects; however, the additive and dose-dependent effects of CoQ10 remain unclear. This study evaluated these effects in women with PCOS.

Methods

In this retrospective study, 200 women with PCOS were assigned to four groups: myoinositol plus CoQ10 100 mg (n = 55), myoinositol plus CoQ10 200 mg (n = 55), myoinositol alone (n = 45), and untreated controls (n = 45). Fasting insulin, HOMA-IR, total testosterone, and menstrual cycle regularity were assessed at baseline and 6 months. Between-group differences were evaluated using multivariable regression analyses and sensitivity analyses.

Results

All treatment groups showed improvements in metabolic and hormonal parameters, with the greatest effects observed in the combination therapy groups. Myoinositol alone was associated with significant reductions in HOMA-IR (β = −0.219; p < 0.001) and total testosterone (β = −3.145; p < 0.001) compared with untreated controls. The addition of CoQ10 resulted in dose-dependent improvements, with 100 and 200 mg doses demonstrating progressively greater reductions in HOMA-IR (β = −0.308 and −0.571, respectively) and total testosterone (β = −2.847 and −5.325, respectively) (all p < 0.001). Multivariable regression analyses confirmed that both CoQ10 doses remained significantly superior to myoinositol monotherapy. Menstrual cycle regularity improved most in the MI + CoQ10 200 mg group (36.4%).

Conclusion

Adjunctive CoQ10 supplementation with myoinositol provides significant and dose-dependent improvements in insulin resistance and hyperandrogenism in PCOS. The magnitude of reduction observed with 200 mg CoQ10 suggests potential clinical relevance, particularly in metabolically compromised patients. Prospective randomized studies are warranted to confirm these findings.

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辅酶Q10联合肌醇对多囊卵巢综合征女性胰岛素抵抗和高雄激素症的加性和剂量依赖性作用：一项回顾性对照研究

目的：多囊卵巢综合征（PCOS）以胰岛素抵抗、高雄激素和生殖功能障碍为特征。肌醇和辅酶Q10 （CoQ10）具有互补的代谢和激素作用；然而，辅酶q10的添加性和剂量依赖性作用尚不清楚。本研究评估了这些对多囊卵巢综合征女性的影响。方法：在这项回顾性研究中，200名PCOS女性被分为四组：肌醇加辅酶q10 100 mg （n = 55）、肌醇加辅酶q10 200 mg （n = 55）、肌醇单独（n = 45）和未经治疗的对照组（n = 45）。在基线和6个月时评估空腹胰岛素、HOMA-IR、总睾酮和月经周期规律。采用多变量回归分析和敏感性分析评估组间差异。结果：各治疗组代谢及激素指标均有改善，以联合治疗组效果最大。结论：辅助辅酶q10补充肌醇可显著改善多囊卵巢综合征患者的胰岛素抵抗和高雄激素症，且具有剂量依赖性。200毫克辅酶q10的降低幅度提示潜在的临床相关性，特别是在代谢受损的患者中。前瞻性随机研究证实了这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.