Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives

IF 4.7

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Pub Date : 2026-09-28 DOI:10.1111/jcmm.71371

Chenrong Jin, Ding Du, Xiaorui Yu, Xiaoyan Ji, Xiuyun Zhang, Anning Li, Shuang Zu, Bo Qu, Daqing Zhao, Dianpeng Wu, Meichen Liu

{"title":"Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives","authors":"Chenrong Jin, Ding Du, Xiaorui Yu, Xiaoyan Ji, Xiuyun Zhang, Anning Li, Shuang Zu, Bo Qu, Daqing Zhao, Dianpeng Wu, Meichen Liu","doi":"10.1111/jcmm.71371","DOIUrl":null,"url":null,"abstract":"<p>Aging is a systemic decline in physiological integrity, driving chronic diseases such as neurodegeneration, cardiovascular disorders, and metabolic syndromes. Rapid global population aging urgently demands effective interventions. Traditional Chinese medicine (TCM) formulas, characterized by multi-component, multi-target, and multi-pathway synergy, offer a promising paradigm for delaying aging. This review systematically integrates recent advances in TCM formula-based anti-aging research, bridging classical TCM gerontology with the 14 modern hallmarks of aging. We categorize representative formulas into four mechanistic groups targeting mitochondrial homeostasis and autophagy, cellular senescence and inflammatory microenvironment, stem cell maintenance and epigenetic reprogramming, and gut microbiota and systemic metabolism, and explore their holistic efficacy, key bioactive constituents, and multi-component synergy. In terms of methodological innovations, we introduced network pharmacology combined with AI-driven target screening and proteomic aging clocks to assess biological age. We discussed challenges in chemical complexity, mechanistic completeness, and clinical translation, and proposed a roadmap for development. This review establishes an integrative model that integrates TCM principles with modern aging biology, offering insights for translational research toward healthy longevity.</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"30 19","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620404/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jcmm.71371","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Aging is a systemic decline in physiological integrity, driving chronic diseases such as neurodegeneration, cardiovascular disorders, and metabolic syndromes. Rapid global population aging urgently demands effective interventions. Traditional Chinese medicine (TCM) formulas, characterized by multi-component, multi-target, and multi-pathway synergy, offer a promising paradigm for delaying aging. This review systematically integrates recent advances in TCM formula-based anti-aging research, bridging classical TCM gerontology with the 14 modern hallmarks of aging. We categorize representative formulas into four mechanistic groups targeting mitochondrial homeostasis and autophagy, cellular senescence and inflammatory microenvironment, stem cell maintenance and epigenetic reprogramming, and gut microbiota and systemic metabolism, and explore their holistic efficacy, key bioactive constituents, and multi-component synergy. In terms of methodological innovations, we introduced network pharmacology combined with AI-driven target screening and proteomic aging clocks to assess biological age. We discussed challenges in chemical complexity, mechanistic completeness, and clinical translation, and proposed a roadmap for development. This review establishes an integrative model that integrates TCM principles with modern aging biology, offering insights for translational research toward healthy longevity.

查看原文本刊更多论文

中药方剂延缓衰老：从理论基础到分子机制和转化视角。

衰老是生理完整性的全身性下降，导致神经退行性疾病、心血管疾病和代谢综合征等慢性疾病。全球人口快速老龄化迫切需要有效的干预措施。中药配方具有多成分、多靶点、多途径协同作用的特点，为延缓衰老提供了一个很有前景的范例。本文系统整合了近年来以中药方剂为基础的抗衰老研究进展，将经典中医老年学与14种现代衰老特征联系起来。我们将代表性配方分为4个机制组，分别针对线粒体稳态和自噬、细胞衰老和炎症微环境、干细胞维持和表观遗传重编程、肠道微生物群和全身代谢，并探讨其整体功效、关键生物活性成分和多组分协同作用。在方法创新方面，我们引入了网络药理学，结合人工智能驱动的靶点筛选和蛋白质组老化时钟来评估生物年龄。我们讨论了化学复杂性、机制完整性和临床翻译方面的挑战，并提出了发展路线图。本文建立了中医原理与现代衰老生物学相结合的综合模型，为健康长寿的转化研究提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CiteScore

11.50

自引率

0.00%

发文量

期刊介绍： The Journal of Cellular and Molecular Medicine serves as a bridge between physiology and cellular medicine, as well as molecular biology and molecular therapeutics. With a 20-year history, the journal adopts an interdisciplinary approach to showcase innovative discoveries. It publishes research aimed at advancing the collective understanding of the cellular and molecular mechanisms underlying diseases. The journal emphasizes translational studies that translate this knowledge into therapeutic strategies. Being fully open access, the journal is accessible to all readers.