Cardiovascular Magnetic Resonance Reference Values for Left Ventricular Diastolic Function and Left Atrial Sphericity Index in Healthy Adults.

IF 5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Magnetic Resonance Pub Date : 2026-09-28 DOI:10.1016/j.jocmr.2026.102802

Yiyuan Gao, Wanzhen Li, Wenqi Liu, Shanshan Zhou, Jingjing Shi, Gengxiao Li, Zhiwei Zhao, Zhenchang Wang, Zhen Zhang, Kuncheng Li, Gerald M Pohost

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引用次数: 0

Abstract

Background: Cardiovascular magnetic resonance (CMR) is increasingly used to quantify volumetric indices reflecting left ventricular (LV) diastolic function. However, normal reference values for CMR-derived volumetric parameters of LV diastolic function and the left atrial sphericity index (LASI) remain limited. This study aimed to establish age- and sex-specific reference values for CMR-derived LV diastolic volumetric parameters and LASI in a large cohort of healthy Chinese adults.

Methods: A total of 503 healthy Chinese adults, rigorously validated by comprehensive health screening, were retrospectively included. A structured literature review was performed to identify candidate CMR-derived volumetric parameters of LV diastolic function, as well as LASI. Based on this review, left atrioventricular coupling index (LACI), left atrial expansion index (LAEI), peak filling rate (PFR), PFR normalized to end-diastolic volume (PFR/EDV), CMR-derived left ventricular filling pressure (LVFP), and LASI were selected and measured from cine CMR images. Reference values were calculated and stratified by sex and age decades. Associations of these CMR-derived parameters with sex and age were evaluated.

Results: Men exhibited significantly lower LACI [0.19 (0.15-0.24) vs. 0.20 (0.17-0.25)], LAEI [146.9 (122.5-181.2) % vs. 161.4 (139.6-202.4) %], PFR/EDV [2.61 (2.25-3.09) s^-1 vs. 2.97 (2.51-3.32) s^-1], and LASI [0.52 (0.46-0.62) vs. 0.59 (0.50-0.68)], but higher absolute PFR [385.4 (325.4-442.6) mL/s vs. 341.2 (290.9-394.9) mL/s] and CMR-derived LVFP [13.2 (12.4-14.4) mmHg vs. 12.3 (11.4-13.1) mmHg] than women (all p < 0.05). With advancing age, LACI increased progressively in both sexes (men: r = 0.20; women: r = 0.24; both p < 0.001), whereas LAEI, PFR, PFR/EDV, and LASI exhibited significant declines (men: r = -0.25, -0.33, -0.21, and -0.22; women: r = -0.22, -0.36, -0.26, and -0.32; all p < 0.001).

Conclusions: This study provides age- and sex-specific reference values for CMR-derived LV diastolic volumetric parameters and LASI in a large cohort of validated healthy Chinese adults. Both age and sex significantly influence these parameters. These normative data support standardized interpretation of CMR-derived diastolic parameters in clinical and research settings, particularly for the Chinese population.

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健康成人左室舒张功能和左心房球度指数的心血管磁共振参考值。

背景：心血管磁共振（CMR）越来越多地用于量化反映左室（LV）舒张功能的容量指标。然而，cmr衍生的左室舒张功能容积参数和左房球度指数（LASI）的正常参考值仍然有限。本研究旨在建立cmr衍生的左室舒张容积参数和LASI的年龄和性别特异性参考值。方法：回顾性分析经综合健康筛查严格验证的503名中国健康成年人。进行了结构化的文献综述，以确定候选的cmr衍生的左室舒张功能容量参数，以及LASI。在此基础上，从CMR电影图像中选择并测量左房室耦合指数（LACI）、左房扩张指数（LAEI）、峰值充盈率（PFR）、PFR归一化至舒张末期容积（PFR/EDV）、CMR衍生的左室充盈压力（LVFP）和LASI。计算参考值并按性别和年龄分层。评估了这些cmr衍生参数与性别和年龄的关系。结果：男性的LACI [0.19 (0.15-0.24) vs. 0.20(0.17-0.25)]、LAEI [146.9 (122.5-181.2) % vs. 161.4(139.6-202.4) %]、PFR/EDV [2.61 (2.25-3.09) s-1 vs. 2.97 (2.51-3.32) s-1]、LASI [0.52 (0.46-0.62) vs. 0.59(0.50-0.68)]显著低于女性，但绝对PFR [385.4 (325.4-442.6) mL/s vs. 341.2 (290.9-394.9) mL/s]和cmr衍生LVFP [13.2 (12.4-14.4) mmHg vs. 12.3 (11.4-13.1) mmHg]高于女性（均p < 0.05）。随着年龄的增长，男女LACI逐渐增加（男性：r = 0.20；女性：r = 0.24；均p < 0.001），而LAEI、PFR、PFR/EDV和LASI则显著下降（男性：r = -0.25、-0.33、-0.21和-0.22；女性：r = -0.22、-0.36、-0.26和-0.32，均p < 0.001）。结论：本研究为cmr衍生的左室舒张容积参数和LASI提供了年龄和性别特异性的参考值。年龄和性别对这些参数有显著影响。这些规范性数据支持临床和研究中cmr衍生舒张参数的标准化解释，特别是对中国人群。

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来源期刊

Journal of Cardiovascular Magnetic Resonance 医学-核医学

CiteScore

10.90

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.