The use of gametes from donors who have undergone expanded carrier screening: a guidance for UK practice.

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-09-29 DOI:10.1080/14647273.2026.2733076

Valerie Shaikly, Mariano Mascarenhas, Anneke Lucassen, Debra Bloor, Saffron Townsend Browne, Karen Thompson, Harish Bhandari

引用次数: 0

Abstract

Expanded carrier screening (ECS) is increasingly offered within assisted reproductive technologies (ART), particularly as a component of donor gamete selection. As genomic testing options rapidly evolve, the complexity of interpreting ECS results presents significant challenges for donor gamete recipients and the healthcare professionals supporting them. At the same time, regulatory frameworks and professional guidelines have not kept pace with these technological developments, resulting in gaps between clinical practice and formal guidance. This paper aims to summarise current practice, highlight emerging issues arising from the integration of ECS into gamete selection, and provide recommendations to facilitate informed decision-making.

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使用接受过扩大携带者筛查的捐赠者的配子：英国实践指南。

扩展载体筛选（ECS）在辅助生殖技术（ART）中越来越多地提供，特别是作为供体配子选择的一个组成部分。随着基因组检测方法的迅速发展，解释ECS结果的复杂性对供体配子接受者和支持他们的医疗保健专业人员提出了重大挑战。与此同时，监管框架和专业指南未能跟上这些技术发展的步伐，导致临床实践与正式指导之间存在差距。本文旨在总结当前的实践，强调将ECS整合到配子选择中出现的新问题，并提供建议以促进明智的决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY

CiteScore

3.30

自引率

5.30%

发文量

期刊介绍： Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.