Effect of FATmax-Intensity Exercise on Body Composition and Cardiovascular Health in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis.

IF 3.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2026-09-24 eCollection Date: 2026-01-01 DOI:10.2147/DMSO.S619590

Ge Zhao, Teng Keen Khong, Yanqing Yan, Ashril Yusof

{"title":"Effect of FATmax-Intensity Exercise on Body Composition and Cardiovascular Health in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis.","authors":"Ge Zhao, Teng Keen Khong, Yanqing Yan, Ashril Yusof","doi":"10.2147/DMSO.S619590","DOIUrl":null,"url":null,"abstract":"Purpose: To determine the effects of exercising at maximal fat oxidation (FATmax) intensity on body composition, cardiorespiratory fitness, and metabolism outcomes in overweight and obese individuals through a systematic review and meta-analysis.Methods: Randomized controlled trials (RCTs) were retrieved from PubMed, Web of Science, CNKI, and the Cochrane Library. Search terms included FATmax or maximal fat oxidation, obesity or overweight, BMI, [Formula: see text], diastolic blood pressure (DBP), systolic blood pressure (SBP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and homeostasis model assessment of insulin resistance (HOMA-IR). Risk of bias was assessed using Cochrane guidelines and the quality of evidence using GRADE. A random-effects model (Stata 16.0) calculated pooled mean differences for outcomes.Results: 18 RCTs were finally analysed. Compared to non-exercising controls, FATmax-intensity exercise improved (i) body composition, including reduced body weight (WMD = -4.43 kg, 95% CI: -5.11, -3.75), fat mass (WMD = -3.68 kg, 95% CI: -4.31, -3.06), waist circumference (WMD = -4.36 cm, 95% CI: -6.73, -1.99), and waist-to-hip ratio (WMD=-0.04, 95% CI: -0.05, -0.03); (ii) cardiorespiratory fitness, evidenced by increased [Formula: see text] (WMD = 3.89 mL/(kg·min), 95% CI: 3.04, 4.74), reduced SBP (WMD = -1.73 mmHg, 95% CI: -6.60, 3.15) and DBP (WMD = -2.10 mmHg, 95% CI: -3.70, -0.49); (iii) metabolism outcomes, such as reduced TG (SMD = -0.80, 95% CI: -1.24, -0.36), TC (SMD = -0.37, 95% CI: -0.72, -0.02), LDL-C (SMD = -0.44, 95% CI:-0.78, -0.10), increased (HDL-C) (SMD = 0.97, 95% CI: 0.64, 1.30) and improved HOMA-IR (SMD = -0.81, 95% CI: -1.44, -0.18). Subgroup analyses suggested that age, sex, and intervention characteristics (eg, duration and frequency) moderated these outcomes to varying degrees.Conclusions: FATmax-intensity exercise confers beneficial effects on body composition, glucose and lipid metabolism, and cardiorespiratory fitness in populations with overweight and obesity. Despite outcome-specific variations and methodological heterogeneity warranting cautious interpretation, FATmax training represents a promising, individualized strategy for cardiometabolic health management.","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"19 ","pages":"619590"},"PeriodicalIF":3.5000,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618583/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/DMSO.S619590","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To determine the effects of exercising at maximal fat oxidation (FATmax) intensity on body composition, cardiorespiratory fitness, and metabolism outcomes in overweight and obese individuals through a systematic review and meta-analysis.

Methods: Randomized controlled trials (RCTs) were retrieved from PubMed, Web of Science, CNKI, and the Cochrane Library. Search terms included FATmax or maximal fat oxidation, obesity or overweight, BMI, [Formula: see text], diastolic blood pressure (DBP), systolic blood pressure (SBP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and homeostasis model assessment of insulin resistance (HOMA-IR). Risk of bias was assessed using Cochrane guidelines and the quality of evidence using GRADE. A random-effects model (Stata 16.0) calculated pooled mean differences for outcomes.

Results: 18 RCTs were finally analysed. Compared to non-exercising controls, FATmax-intensity exercise improved (i) body composition, including reduced body weight (WMD = -4.43 kg, 95% CI: -5.11, -3.75), fat mass (WMD = -3.68 kg, 95% CI: -4.31, -3.06), waist circumference (WMD = -4.36 cm, 95% CI: -6.73, -1.99), and waist-to-hip ratio (WMD=-0.04, 95% CI: -0.05, -0.03); (ii) cardiorespiratory fitness, evidenced by increased [Formula: see text] (WMD = 3.89 mL/(kg·min), 95% CI: 3.04, 4.74), reduced SBP (WMD = -1.73 mmHg, 95% CI: -6.60, 3.15) and DBP (WMD = -2.10 mmHg, 95% CI: -3.70, -0.49); (iii) metabolism outcomes, such as reduced TG (SMD = -0.80, 95% CI: -1.24, -0.36), TC (SMD = -0.37, 95% CI: -0.72, -0.02), LDL-C (SMD = -0.44, 95% CI:-0.78, -0.10), increased (HDL-C) (SMD = 0.97, 95% CI: 0.64, 1.30) and improved HOMA-IR (SMD = -0.81, 95% CI: -1.44, -0.18). Subgroup analyses suggested that age, sex, and intervention characteristics (eg, duration and frequency) moderated these outcomes to varying degrees.

Conclusions: FATmax-intensity exercise confers beneficial effects on body composition, glucose and lipid metabolism, and cardiorespiratory fitness in populations with overweight and obesity. Despite outcome-specific variations and methodological heterogeneity warranting cautious interpretation, FATmax training represents a promising, individualized strategy for cardiometabolic health management.

查看原文本刊更多论文

fatmax强度运动对超重和肥胖个体身体成分和心血管健康的影响：一项系统综述和荟萃分析

目的：通过系统回顾和荟萃分析，确定在最大脂肪氧化（FATmax）强度下运动对超重和肥胖个体的身体组成、心肺健康和代谢结果的影响。方法：随机对照试验（rct）从PubMed、Web of Science、CNKI和Cochrane Library检索。搜索词包括FATmax或最大脂肪氧化，肥胖或超重，BMI，[公式：见文本]，舒张压（DBP），收缩压（SBP），甘油三酯（TG），总胆固醇（TC），高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C）和胰岛素抵抗的稳态模型评估（HOMA-IR）。使用Cochrane指南评估偏倚风险，使用GRADE评估证据质量。随机效应模型（Stata 16.0）计算结果的汇总平均差异。结果：最终分析了18项rct。与不运动的对照组相比，fatmax强度运动改善了(1)身体组成，包括体重（WMD= -4.43 kg, 95% CI: -5.11, -3.75）、脂肪量（WMD= -3.68 kg, 95% CI: -4.31, -3.06）、腰围（WMD= -4.36 cm, 95% CI: -6.73, -1.99）和腰臀比（WMD=-0.04, 95% CI: -0.05, -0.03）；（ii）心肺健康，增加[公式：见文](WMD = 3.89 mL/(kg·min), 95% CI: 3.04, 4.74)，降低收缩压（WMD = -1.73 mmHg, 95% CI: -6.60, 3.15）和舒张压（WMD = -2.10 mmHg, 95% CI: -3.70, -0.49）；（iii）代谢结果，如TG降低（SMD = -0.80, 95% CI: -1.24, -0.36）、TC （SMD = -0.37, 95% CI: -0.72, -0.02）、LDL-C （SMD = -0.44, 95% CI:-0.78, -0.10）、HDL-C升高（SMD = 0.97, 95% CI: 0.64, 1.30）和HOMA-IR改善（SMD = -0.81, 95% CI: -1.44, -0.18）。亚组分析表明，年龄、性别和干预特征（如持续时间和频率）在不同程度上减缓了这些结果。结论：fatmax强度运动对超重和肥胖人群的身体组成、糖脂代谢和心肺健康有有益影响。尽管结果特异性差异和方法异质性需要谨慎解释，但FATmax训练代表了一种有希望的、个性化的心脏代谢健康管理策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.