Time-dependent prognostic value of perioperative changes in the systemic inflammation response index for overall survival in oral tongue squamous cell carcinoma: a retrospective cohort study.
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引用次数: 0
Abstract
Objectives: To investigate the association between perioperative changes in the systemic inflammation response index (SIRI) and overall survival (OS) in patients with oral tongue squamous cell carcinoma (OTSCC), with a focus on its time-dependent prognostic value.
Materials and methods: This single-center retrospective cohort study included 264 patients with primary OTSCC who underwent curative-intent resection between June 2015 and February 2025. ΔSIRI was defined as postoperative SIRI minus preoperative SIRI. Time-dependent receiver operating characteristic (ROC) analysis was used to derive the ΔSIRI cutoff. Survival analyses included Kaplan-Meier curves, Cox regression, restricted mean survival time (RMST), and time-varying coefficient Cox models.
Results: During follow-up, 70 deaths occurred. In multivariable Cox analysis, high ΔSIRI was significantly associated with poorer OS (adjusted hazard ratio [HR] = 2.13, 95% confidence interval [CI]: 1.24-3.67, P = 0.006). Adjusted RMST analysis showed an 8.02-month reduction in restricted mean survival time in the high ΔSIRI group within 60 months compared with the low ΔSIRI group (95% CI: - 12.76 to - 3.28, P < 0.001). The time-varying coefficient Cox model indicated that the adverse prognostic association of high ΔSIRI was most pronounced during the early follow-up period and gradually attenuated over time.
Conclusions: High perioperative ΔSIRI was associated with poorer OS in patients with OTSCC. ΔSIRI may serve as an adjunctive dynamic inflammatory-immune marker for early postoperative risk stratification, although external validation is warranted.
Clinical relevance: Perioperative ΔSIRI may provide supplementary information for identifying patients with OTSCC at higher early postoperative mortality risk.
期刊介绍：
The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.
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