Design of a yeast-based bio-interface on an optical fiber SPR platform toward drug adsorption monitoring.

IF 3.5 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Beilstein Journal of Nanotechnology Pub Date : 2026-09-22 eCollection Date: 2026-01-01 DOI:10.3762/bjnano.17.89

Natsumi Kitaya, Daisuke Yamanaka, Kenji Morita, Ryota Naito, Hinako Suhara, Kento Suzuki, Hizuru Nakajima, Yukiko Moriiwa, Kazuhiro Morioka, Akio Yanagida, Atsushi Shoji

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引用次数: 0

Abstract

Yeast biomass, Saccharomyces cerevisiae, has been widely studied for removing heavy metals and organic pollutants, including pharmaceuticals. However, conventional batch methods provide limited insight into time-resolved adsorption and interfacial molecular interactions. We developed an optical fiber-based surface plasmon resonance (SPR) sensor incorporating a yeast-derived bio-interface. A film formation monitoring method based on transmitted light absorbance during electroless Ni plating enabled reproducible fabrication of gold nanofilms. Yeast cells were uniformly immobilized via a spray-based method to construct the bio-interface. Using this sensor, real-time adsorption of pharmaceuticals onto yeast cells was evaluated: Doxorubicin showed a concentration-dependent SPR response, whereas ampicillin showed no significant change in SPR response. The optical fiber configuration allows for direct immersion into environmental waters for in situ measurements, providing a platform for dynamic analysis of microorganism-pollutant interactions and advancing water treatment and environmental monitoring technologies.

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用于药物吸附监测的光纤SPR平台酵母生物界面设计。

酵母生物质（Saccharomyces cerevisiae）已被广泛研究用于去除重金属和有机污染物，包括药物。然而，传统的批处理方法对时间分辨吸附和界面分子相互作用提供了有限的见解。我们开发了一种基于光纤的表面等离子体共振（SPR）传感器，该传感器结合了酵母衍生的生物界面。化学镀镍过程中基于透射光吸收的膜形成监测方法实现了金纳米膜的可重复性制备。采用喷雾法均匀固定酵母细胞，构建生物界面。使用该传感器，评估了药物在酵母细胞上的实时吸附：阿霉素显示出浓度依赖的SPR响应，而氨苄西林在SPR响应方面没有显著变化。光纤配置允许直接浸入环境水中进行原位测量，为微生物-污染物相互作用的动态分析提供平台，并推进水处理和环境监测技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Beilstein Journal of Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

5.70

自引率

3.20%

发文量

109

审稿时长

2 months

期刊介绍： The Beilstein Journal of Nanotechnology is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in nanoscience and nanotechnology. The journal is published and completely funded by the Beilstein-Institut, a non-profit foundation located in Frankfurt am Main, Germany. The editor-in-chief is Professor Thomas Schimmel – Karlsruhe Institute of Technology. He is supported by more than 20 associate editors who are responsible for a particular subject area within the scope of the journal.