Dual-Targeted Therapy With Upadacitinib and Ustekinumab in Pediatric Refractory Perianal Crohn's Disease.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2026-09-28 eCollection Date: 2026-10-01 DOI:10.14309/crj.0000000000002331

Neha Sathe, Meredith Kline, Amelia Kellar, David Choi, Ranjana Gokhale

引用次数: 0

Abstract

Perianal Crohn's disease (pCD) is a challenging manifestation of CD. We present the case of a 17-year-old adolescent girl with severe, refractory pCD, complicated by a rectovaginal fistula, who failed multiple lines of therapy and required a temporary ileostomy. While on upadacitinib (UPA) monotherapy, she experienced a flare with magnetic resonance imaging (MRI)-confirmed perianal abscesses. The addition of ustekinumab (UST) to UPA resulted in marked improvement in clinical symptoms and radiographic resolution of perianal disease on follow-up MRI. No adverse events occurred. This case highlights dual UPA/UST therapy as a promising strategy for severe, refractory pCD in an adolescent.

查看原文本刊更多论文

Upadacitinib和Ustekinumab双靶向治疗小儿难治性肛周克罗恩病

肛周克罗恩病（pCD）是一种具有挑战性的CD表现。我们报告了一个17岁的青春期女孩，患有严重的难治性pCD，并发直肠阴道瘘，多次治疗失败，需要临时回肠造口术。在upadacitinib （UPA）单药治疗期间，她经历了一次核磁共振成像（MRI）证实的肛周脓肿。ustekinumab （UST）加入UPA后，临床症状显著改善，随访MRI显示肛周疾病的影像学改善。无不良事件发生。该病例强调了双重UPA/UST治疗作为青少年严重难治性pCD的有希望的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.