Synthesis of 3-acylated 1-aminoisoquinolin-4-ols via construction of a fully substituted pyridine moiety.

IF 2.8 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2026-10-14 DOI:10.1039/d6ob00919k

Nayeon Kim, Sunhee Lee, Ikyon Kim

引用次数: 0

Abstract

Described herein is an annulative functionalization approach to synthesize the 3-acylated 1-aminoisoquinolin-4-ol skeleton from a base-catalyzed reaction of 2-formylbenzonitrile with α-azidoketone under mild conditions, enabling the facile assembly of a fully functionalized aminopyridinol moiety via a domino procedure involving an aldol reaction, imine formation, tautomerization, and cycloisomerization.

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通过构建全取代吡啶片段合成3-酰化1-氨基异喹啉-4-醇。

本文描述了一种环化功能化方法，通过2-甲酰苯腈与α-叠氮酮在温和条件下的碱催化反应合成3-酰基化的1-氨基异喹啉-4-醇骨架，通过涉及醛醇反应、亚胺形成、互变异构化和环异构化的多米诺骨牌过程，使完全功能化的氨基吡啶醇部分易于组装。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.