Microwave-assisted combinatorial synthesis of phalloidin derivatives for optimization of structure-activity-relationship (SAR).

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2026-10-20 DOI:10.1039/d6cc05246k

Tino Damaszek, Mark A R de Geus, Zhanyu He, Guiyang Yao, Christian P R Hackenberger, Roderich D Süssmuth

引用次数: 0

Abstract

A microwave-assisted approach enables the rapid synthesis of a comprehensive library of phalloidin derivatives. Actin polymerization assays reveal several compounds that exhibit an enhanced rate of F-actin polymerization compared to the native toxin.

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微波辅助组合合成phalloidin衍生物的构效关系优化。

微波辅助方法可以快速合成一个全面的phalloidin衍生物库。肌动蛋白聚合试验显示，与天然毒素相比，几种化合物表现出增强的f -肌动蛋白聚合率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.