Assessment of Factors and Trends Affecting Different Pathological Types of Cervical Cancer in China From 2013 to 2022.

IF 3.5 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2026-10-01 DOI:10.1002/cam4.72259

Yufei Li, Runhua Li, Rufei Duan, Xiaofen Gu, Jia You, Hong Wang, Tingting Zuo, Zhe Wang, Weizhao Lin, Li Li, Bo Zhu, Shaokai Zhang, Wen Yang, Shuai Yuan, Hongping Zhang, Lingbin Du, Jian Yin, Huan Yang, Youlin Qiao

{"title":"Assessment of Factors and Trends Affecting Different Pathological Types of Cervical Cancer in China From 2013 to 2022.","authors":"Yufei Li, Runhua Li, Rufei Duan, Xiaofen Gu, Jia You, Hong Wang, Tingting Zuo, Zhe Wang, Weizhao Lin, Li Li, Bo Zhu, Shaokai Zhang, Wen Yang, Shuai Yuan, Hongping Zhang, Lingbin Du, Jian Yin, Huan Yang, Youlin Qiao","doi":"10.1002/cam4.72259","DOIUrl":null,"url":null,"abstract":"Objective: Cervical cancer poses a significant burden globally, particularly in developing countries, with China accounting for 20% of the global incidence. This study aimed to examine temporal changes in the pathological distribution of cervical cancer, particularly squamous cell carcinoma (SCC) and adenocarcinoma (ADC), in China from 2013 to 2022.Methods: A nationwide, multicenter, retrospective study analyzed 6645 cervical cancer cases diagnosed between 2013 and 2022 across seven tertiary hospitals in China. The study analyzed demographic, obstetric, and reproductive factors to identify trends in the proportions of SCC and ADC. Multivariable logistic regression was further performed among women with SCC or ADC to identify factors independently associated with histological type.Results: SCC accounted for 86.9% and ADC for 10.4% of invasive cervical cancer (ICC) cases. Although no significant change in SCC proportion was observed overall, declines were observed in specific subgroups-unemployed women, premenopausal women, and those with a history of reproductive system disease (ptrend = 0.012, 0.021, and 0.011, respectively). In multivariable analysis, compared with Central China, the odds of ADC relative to SCC were significantly higher in North China, Southwest China, East China, and South China, whereas menopausal women, Uyghur women, and rural residents showed lower odds of ADC relative to SCC.Conclusions: Although the overall proportion of SCC among ICC cases remained statistically stable during 2013-2022, SCC showed a decreasing trend in several high-risk subpopulations. Compared with our 2005-2010 series, the present 2013-2022 study showed a higher ADC proportion and a lower SCC proportion. These findings suggest a gradual shift in the pathological landscape of ICC in China and provide up-to-date nationwide multicenter data that may help refine future screening and prevention strategies.","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"15 10","pages":"e72259"},"PeriodicalIF":3.5000,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620289/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cam4.72259","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Cervical cancer poses a significant burden globally, particularly in developing countries, with China accounting for 20% of the global incidence. This study aimed to examine temporal changes in the pathological distribution of cervical cancer, particularly squamous cell carcinoma (SCC) and adenocarcinoma (ADC), in China from 2013 to 2022.

Methods: A nationwide, multicenter, retrospective study analyzed 6645 cervical cancer cases diagnosed between 2013 and 2022 across seven tertiary hospitals in China. The study analyzed demographic, obstetric, and reproductive factors to identify trends in the proportions of SCC and ADC. Multivariable logistic regression was further performed among women with SCC or ADC to identify factors independently associated with histological type.

Results: SCC accounted for 86.9% and ADC for 10.4% of invasive cervical cancer (ICC) cases. Although no significant change in SCC proportion was observed overall, declines were observed in specific subgroups-unemployed women, premenopausal women, and those with a history of reproductive system disease (p_trend = 0.012, 0.021, and 0.011, respectively). In multivariable analysis, compared with Central China, the odds of ADC relative to SCC were significantly higher in North China, Southwest China, East China, and South China, whereas menopausal women, Uyghur women, and rural residents showed lower odds of ADC relative to SCC.

Conclusions: Although the overall proportion of SCC among ICC cases remained statistically stable during 2013-2022, SCC showed a decreasing trend in several high-risk subpopulations. Compared with our 2005-2010 series, the present 2013-2022 study showed a higher ADC proportion and a lower SCC proportion. These findings suggest a gradual shift in the pathological landscape of ICC in China and provide up-to-date nationwide multicenter data that may help refine future screening and prevention strategies.

查看原文本刊更多论文

2013 - 2022年中国不同病理类型宫颈癌影响因素及趋势分析

目的：宫颈癌在全球范围内，特别是在发展中国家造成了重大负担，其中中国占全球发病率的20%。本研究旨在研究2013年至2022年中国宫颈癌病理分布的时间变化，特别是鳞状细胞癌（SCC）和腺癌（ADC）。方法：一项全国性、多中心、回顾性研究分析了2013年至2022年中国7家三级医院诊断的6645例宫颈癌病例。该研究分析了人口统计学、产科和生殖因素，以确定SCC和ADC比例的趋势。进一步对患有SCC或ADC的女性进行多变量logistic回归，以确定与组织学类型独立相关的因素。结果：浸润性宫颈癌（ICC）中SCC占86.9%，ADC占10.4%。虽然总体上没有观察到SCC比例的显著变化，但在特定的亚组-失业妇女、绝经前妇女和有生殖系统疾病史的妇女中观察到下降（p趋势分别为0.012、0.021和0.011）。在多变量分析中，与华中地区相比，华北、西南、华东和华南地区的ADC相对于SCC的几率显著较高，而更年期妇女、维吾尔族妇女和农村居民的ADC相对于SCC的几率较低。结论：虽然在2013-2022年期间，SCC在ICC病例中的总体比例在统计上保持稳定，但SCC在几个高危亚人群中呈下降趋势。与我们2005-2010年的研究相比，2013-2022年的研究显示ADC比例更高，SCC比例更低。这些发现提示了中国ICC病理格局的逐渐转变，并提供了最新的全国多中心数据，可能有助于完善未来的筛查和预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.