Extract of Cissus sicyoides L. modulates metabolic biomarkers in an intergenerational obesity model.

Q2 Medicine

Journal of Complementary and Integrative Medicine Pub Date : 2026-09-29 DOI:10.1515/jcim-2026-0131

Andre Cantarelli Vilela, João Vitor Alves Damacena, Gabriel Stefanini, Vanessa Tizzo Teixeira, Paula Becker Pertuzatti Konda, Kleber Eduardo de Campos

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引用次数: 0

Abstract

Objectives: This study aimed to evaluate its metabolic effects of Cissus sicyoides L. aqueous extract treatment in Wistar rats subjected to an intergenerational obesity model.

Methods: Male offspring (F1 generation) of female rats with monosodium glutamate-induced obesity (F0 generation) were classified as non-obese and obese in adulthood based on the Lee index, and were treated with an aqueous extract of C. sicyoides (8.91 mg/kg) for 28 days. Phenolic compounds in the extract were identified by HPLC-DAD-ESI-MSn. Metabolic parameters, including body mass, food and water intake, biochemical markers, and renal function, were evaluated.

Results: Treatment with C. sicyoides extract reduced glycemia and non-HDL cholesterol levels in obese rats. Additionally, decreases in body mass, Lee index, and relative liver weight were observed. A total of 11 phenolic compounds were identified, including flavonoids and phenolic acids.

Conclusions: The extract of C. sicyoides in an intergenerational obesity rat model showed reductions in glycemia, non-HDL cholesterol, and body weight, as well as modulation of hepatic parameters, suggesting its use as an adjuvant strategy in metabolic disorders.

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枸杞子提取物调节代际肥胖模型中的代谢生物标志物。

目的：研究水仙水提物对代际肥胖模型Wistar大鼠的代谢作用。方法：将谷氨酸钠致肥胖雌性大鼠（F0代）的雄性后代（F1代）按Lee指数分为非肥胖和成年期肥胖两组，用谷氨酸钠致肥胖雌性大鼠水提液（8.91 mg/kg）处理28 d。采用HPLC-DAD-ESI-MSn对提取物中的酚类化合物进行鉴定。代谢参数包括体重、食物和水的摄入量、生化指标和肾功能。结果：枸杞提取物可降低肥胖大鼠的血糖和非高密度脂蛋白胆固醇水平。此外，还观察到体重、Lee指数和相对肝脏重量下降。共鉴定出11种酚类化合物，包括黄酮类和酚酸类。结论：在代际肥胖大鼠模型中，三叶草提取物显示出血糖、非高密度脂蛋白胆固醇和体重的降低，以及肝脏参数的调节，表明其可作为代谢性疾病的辅助策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Complementary and Integrative Medicine Medicine-Complementary and Alternative Medicine

CiteScore

3.10

自引率

0.00%

发文量

期刊介绍： Journal of Complementary and Integrative Medicine (JCIM) focuses on evidence concerning the efficacy and safety of complementary medical (CM) whole systems, practices, interventions and natural health products, including herbal and traditional medicines. The journal is edited by Ed Lui of the University of Western Ontario. Topics: -Quality, efficacy, and safety of natural health products, dietary supplements, traditional medicines and their synthetic duplicates -Efficacy and safety of complementary therapies -Evidence-based medicine and practice, including evidence of traditional use -Curriculum development, educational system and competency of complementary health programs -Methodologies on research and evaluation of traditional medicines and herbal products -Integrative medicine: basic and clinical research and practice -Innovation in CAM Curriculum -Educational Material Design