Donor–Acceptor Bridging via Twisted Quasi-Double-Bond: A Facile Design Strategy for Typical NIR-II AIEgen with “Simple” Structure

IF 6.7

Chemical & Biomedical Imaging Pub Date : 2026-09-28 Epub Date: 2026-04-08 DOI:10.1021/cbmi.5c00302

Chunbin Li, Jen-Shyang Ni, Pengfei Zhang, Daoyong Jiang, Jianguo Wang, Kai Li, Shuang-Quan Zang, Ryan T. K. Kwok, Weihong Tan, Ben Zhong Tang

引用次数: 0

Abstract

A facile design strategy for NIR-II fluorophores with aggregation-induced emission (AIE) characteristics was presented. This kind of NIR-II AIE luminogen, TSPCI is an example, is by the strong acceptor–donor bridging via a twisted quasi-double-bond (TQDB). Theoretical calculations revealed that the introduction of TQDB was the major factor for quenching of the photoexcited TSPCI molecule in the solution state. TSPCI showed excellent NIR-II imaging performance for in vivo dynamic imaging with high contrast and penetration depth. TSPCI holds great potential as a building block to easily fabricate activatable fluorescent probes with superior responsive ability in the second NIR optical window for in vivo imaging applications.

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扭曲准双键给受体桥接：典型NIR-II结构“简单”的简易设计策略

提出了一种具有聚集诱导发光（AIE）特性的NIR-II荧光团的简易设计策略。以TSPCI为例，这种NIR-IIAIE发光材料是通过扭曲准双键（TQDB）实现强受体-供体桥接的。理论计算表明，TQDB的引入是光激TSPCI分子在溶液状态下猝灭的主要因素。TSPCI具有良好的NIR-II成像性能，具有高对比度和穿透深度。TSPCI具有巨大的潜力，可以在第二近红外光学窗口中轻松制造具有卓越响应能力的可激活荧光探针，用于体内成像应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical & Biomedical Imaging 化学与生物成像-

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： Chemical & Biomedical Imaging is a peer-reviewed open access journal devoted to the publication of cutting-edge research papers on all aspects of chemical and biomedical imaging. This interdisciplinary field sits at the intersection of chemistry physics biology materials engineering and medicine. The journal aims to bring together researchers from across these disciplines to address cutting-edge challenges of fundamental research and applications.Topics of particular interest include but are not limited to:Imaging of processes and reactionsImaging of nanoscale microscale and mesoscale materialsImaging of biological interactions and interfacesSingle-molecule and cellular imagingWhole-organ and whole-body imagingMolecular imaging probes and contrast agentsBioluminescence chemiluminescence and electrochemiluminescence imagingNanophotonics and imagingChemical tools for new imaging modalitiesChemical and imaging techniques in diagnosis and therapyImaging-guided drug deliveryAI and machine learning assisted imaging