RETRACTION: Loss of TET1 Facilitates DLD1 Colon Cancer Cell Migration via H3K27me3-Mediated Down-Regulation of E-Cadherin

Abstract

RETRACTION: Z. Zhou, H.-S. Zhang, Y. Liu, Z.-G. Zhang, G.-Y. Du, H. Li, X.-Y. Yu, and Y.-H. Huang, “Loss of TET1 Facilitates DLD1 Colon Cancer Cell Migration via H3K27me3-Mediated Down-Regulation of E-Cadherin,” Journal of Cellular Physiology 233, no. 2 (2018): 1359–1369, https://doi.org/10.1002/jcp.26012.

The above article, published online on 17 May 2017 in Wiley Online Library (https://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Robert Heath; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by a third party on PubPeer [1], which revealed inappropriate figure overlaps and suspected image manipulations in Figure 1c among the three columns; Figure 2c partial overlaps within the images shTET1(1) and shTET1(2); and partial overlaps within the images Figure 6b EZH2 and siUTX-1. In addition, concerns were raised about all Western blots in the article, specifically, that the background appears to be very bright due to overly adjusted contrast. Although the corresponding author was responsive and provided a correction of overlapped figures and also shared the original Western blots during the investigation, the Editor-in-Chief and the publisher have decided that a correction could not resolve the concerns raised for this paper. Therefore, the Editor-in-Chief has lost faith in the reliability of the presented results, and the article must be retracted. The authors disagree with the retraction.

References

[1] S. consimilis, “Loss of TET1 facilitates DLD1 colon cancer cell migration via H3K27me3-mediated down-regulation of E-cadherin,” PubPeer, 2024, https://pubpeer.com/publications/FE83376A7CF1DA6D632CA15B7219AE.