Evaluation of serum myelin basic protein in POAG patients at a tertiary institution in Lagos, Nigeria.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

International Ophthalmology Pub Date : 2026-09-26 DOI:10.1007/s10792-026-04275-5

Judith Ogechi Anikwenwa, Adetunji Olusesan Adenekan, Adegboyega Sunday Alabi, Oluwatobi Olalekan Idowu, Ademola Ayoda Sule, Olufisayo Temitayo Aribaba, Solomon Oladapo Rotimi, Adeola Olukorede Onakoya

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引用次数: 0

Abstract

Purpose: Glaucoma, a neurodegenerative disorder, causes retinal ganglion cell damage and loss of neurons in the visual system up to the visual cortex. The loss of myelin sheath leads to the release of myelin sheath components, including the myelin basic protein (MBP), into the bloodstream. While MBP has shown promise as a biomarker for glaucoma in some Asian populations, data among individuals of African descent remain limited. This study evaluated the serum levels of MBP in primary open-angle glaucoma (POAG) patients compared to non-glaucoma controls, with the aim of reporting its usefulness as a biomarker for glaucoma detection in an African population.

Methods: This cross-sectional study compared serum MBP levels in treatment-naive primary open-angle glaucoma (POAG) patients and non-glaucoma controls. Blood samples were collected from 83 treatment-naive POAG participants and 83 age and sex matched non-glaucoma participants and analyzed using enzyme-linked immunosorbent assay (ELISA).

Results: The mean age of POAG participants was 50.78 ± 17.3 years, with a male predilection. The mean intraocular pressure (IOP) was significantly higher in POAG patients (18.22 ± 6.8 mmHg) than in controls (13.89 ± 2.5 mmHg). Serum MBP levels were significantly elevated in POAG patients (1128.75 ng/L) compared to controls (963.75 ng/L; p < 0.001). There was no significant correlation between MBP levels and disease severity. MBP levels were higher in high-tension glaucoma and females; however, the difference was not statistically significant.

Conclusion: Findings supported the neurodegenerative state of POAG and the use of serum MBP levels as a potential biomarker for early POAG detection.

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尼日利亚拉各斯一所高等院校POAG患者血清髓鞘碱性蛋白的评估。

目的：青光眼是一种神经退行性疾病，导致视网膜神经节细胞损伤和视觉系统直至视觉皮层神经元的丧失。髓鞘的损失导致髓鞘成分的释放，包括髓鞘碱性蛋白（MBP），进入血液。虽然MBP在一些亚洲人群中显示出作为青光眼生物标志物的希望，但非洲裔个体的数据仍然有限。本研究评估了原发性开角型青光眼（POAG）患者与非青光眼对照者的血清MBP水平，目的是报告其作为非洲人群青光眼检测的生物标志物的有效性。方法：本横断面研究比较了未接受治疗的原发性开角型青光眼（POAG）患者和非青光眼对照组的血清MBP水平。83名未经治疗的POAG参与者和83名年龄和性别匹配的非青光眼参与者采集了血液样本，并使用酶联免疫吸附试验（ELISA）进行分析。结果：POAG参与者的平均年龄为50.78±17.3岁，以男性为主。POAG患者的平均眼压（IOP）（18.22±6.8 mmHg）明显高于对照组（13.89±2.5 mmHg）。与对照组（963.75 ng/L）相比，POAG患者血清MBP水平显著升高（1128.75 ng/L）； p结论：研究结果支持POAG的神经退行性状态，并支持将血清MBP水平作为早期POAG检测的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.