Anxiety Symptoms and Risk of Dementia Progression in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.

IF 2.5 4区医学 Q3 CLINICAL NEUROLOGY

Dementia and Geriatric Cognitive Disorders Pub Date : 2026-09-25 DOI:10.1159/dem/aciag007

David Fresnais, Brynjar Fure

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引用次数: 0

Abstract

Introduction: Anxiety is among the earliest and most common neuropsychiatric symptoms in cognitive impairment. Emerging evidence suggests that anxiety may elevate the risk of cognitive decline in mild cognitive impairment (MCI). This systematic review and meta-analysis was performed to quantitatively synthesize evidence from cohort studies on the association between anxiety symptoms and dementia conversion in MCI.

Methods: A systematic literature search was performed in Medline and other relevant databases to find cohort studies examining the association between anxiety symptoms and dementia progression in MCI.

Results: Fifteen cohort studies were included in the systematic review, of which fourteen were included in meta-analyses. Anxiety was significantly associated with an increased risk of all cause dementia, HR = 1.25; 95% CI, 1.11-1.41; p < 0.001, and Alzheimer's disease, HR = 1.32; 95% CI, 1.16-1.49; p < 0.001, while pooled odds ratios did not show a significant association OR = 1.15; 95% CI, 0.84-1.57; p = 0.39.

Conclusion: Anxiety symptoms may be associated with an elevated risk of dementia conversion in MCI. Further large-scale prospective cohort studies are needed to determine the strength and clinical importance of these findings.

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轻度认知障碍患者的焦虑症状和痴呆进展风险：一项系统综述和荟萃分析

焦虑是认知障碍中最早和最常见的神经精神症状之一。新出现的证据表明，焦虑可能会增加轻度认知障碍（MCI）患者认知能力下降的风险。本系统综述和荟萃分析旨在定量综合来自MCI患者焦虑症状与痴呆转化相关性队列研究的证据。方法：在Medline和其他相关数据库中进行系统的文献检索，以查找检查MCI患者焦虑症状与痴呆进展之间关系的队列研究。结果：系统评价纳入了15项队列研究，其中14项纳入了荟萃分析。焦虑与全因痴呆风险增加显著相关，HR = 1.25；95% ci, 1.11-1.41；p < 0.001，阿尔茨海默病，HR = 1.32；95% ci, 1.16-1.49；p < 0.001，但合并优势比未显示显著相关性OR = 1.15；95% ci, 0.84-1.57；P = 0.39。结论：轻度认知损伤患者的焦虑症状可能与痴呆转化风险升高有关。需要进一步的大规模前瞻性队列研究来确定这些发现的强度和临床重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dementia and Geriatric Cognitive Disorders 医学-精神病学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： As a unique forum devoted exclusively to the study of cognitive dysfunction, ''Dementia and Geriatric Cognitive Disorders'' concentrates on Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field.