The Impact of Laser Energy Levels on In Situ Fenestrations of Aortic Stent Grafts: An On-Bench Study.

IF 4.4 3区医学 Q2 ENGINEERING, BIOMEDICAL

Bioengineering Pub Date : 2026-09-19 DOI:10.3390/bioengineering13091085

Teodora Ormandzhieva, Florian Elger, Marcello Silvano, Bernd Niemann, Eberhard Grambow

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引用次数: 0

Abstract

(1) Background: Laser in situ fenestration (L-ISF) is an endovascular technique used to preserve target vessel patency in urgent or emergency endovascular aortic repair when fenestrated/branched solutions are unavailable or unsuitable, or as a bailout technique for fenestration or branch misalignment. This on-bench study compared different laser energy levels in five commercially available endografts to assess fabric damage and evaluate fenestration quality, dimensions, and recoil. (2) Methods: A total of 102 fenestrations were created using a 2.0 mm excimer laser catheter at low (45 mJ/mm²) or high (60 mJ/mm²) energy levels and dilated with a 6 mm plain balloon in five polyester endografts (Zenith Alpha, RelayPro, Endurant IIs, Valiant Captivia, Hercules). High-magnification microscopy assessed morphology and fabric damage after puncture, after dilation, and after 24 h. Quantitative measurements included diameters, area, and recoil under standardized study conditions. (3) Results: Valiant exhibited clearer puncture margins and no bulging; Hercules showed frequent tearing and more bulging and warp-aligned recoil at high energy. In Endurant IIs, low-energy L-ISF produced larger diameters and area but also greater recoil. RelayPro revealed stronger surface recoil with high energy. (4) Conclusion: Both low- and high-energy L-ISF were feasible across all tested grafts. A low-energy approach may be preferable for Endurant IIs, potentially reducing the risk of bridging stent graft stenosis.

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激光能量水平对主动脉支架原位开窗的影响：一项实验研究。

(1)背景：激光原位开窗（L-ISF）是一种血管内技术，用于在紧急或紧急血管内主动脉修复中，当开窗/分支溶液不可用或不合适时，或作为开窗或分支不对准的救助技术，以保持目标血管的通畅。本实验比较了5种市售内移植物的不同激光能量水平，以评估织物损伤和开窗质量、尺寸和后坐力。(2)方法：使用2.0 mm准分子激光导管在低（45 mJ/mm2）或高（60 mJ/mm2）能量水平下创建102个开窗，并用6 mm普通球囊在5个聚酯内植物（Zenith Alpha, RelayPro, Endurant IIs, Valiant Captivia, Hercules）中进行扩张。高倍显微镜评估了穿刺后、扩张后和24小时后的形态学和织物损伤。定量测量包括标准化研究条件下的直径、面积和后坐力。(3)结果：Valiant穿刺边缘清晰，无鼓包；大力神在高能量下表现出频繁的撕裂和更多的膨胀和翘曲后坐力。在endurance ii中，低能量的L-ISF产生了更大的直径和面积，但后坐力也更大。RelayPro显示出更强的表面后坐力和高能量。(4)结论：低能和高能L-ISF在所有移植物中均是可行的。低能量入路可能更适合耐用ii型患者，潜在地降低桥接支架狭窄的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioengineering Chemical Engineering-Bioengineering

CiteScore

4.00

自引率

8.70%

发文量

661

期刊介绍： Aims Bioengineering (ISSN 2306-5354) provides an advanced forum for the science and technology of bioengineering. It publishes original research papers, comprehensive reviews, communications and case reports. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. All aspects of bioengineering are welcomed from theoretical concepts to education and applications. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, four key features of this Journal: ● We are introducing a new concept in scientific and technical publications “The Translational Case Report in Bioengineering”. It is a descriptive explanatory analysis of a transformative or translational event. Understanding that the goal of bioengineering scholarship is to advance towards a transformative or clinical solution to an identified transformative/clinical need, the translational case report is used to explore causation in order to find underlying principles that may guide other similar transformative/translational undertakings. ● Manuscripts regarding research proposals and research ideas will be particularly welcomed. ● Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. ● We also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds. Scope ● Bionics and biological cybernetics: implantology; bio–abio interfaces ● Bioelectronics: wearable electronics; implantable electronics; “more than Moore” electronics; bioelectronics devices ● Bioprocess and biosystems engineering and applications: bioprocess design; biocatalysis; bioseparation and bioreactors; bioinformatics; bioenergy; etc. ● Biomolecular, cellular and tissue engineering and applications: tissue engineering; chromosome engineering; embryo engineering; cellular, molecular and synthetic biology; metabolic engineering; bio-nanotechnology; micro/nano technologies; genetic engineering; transgenic technology ● Biomedical engineering and applications: biomechatronics; biomedical electronics; biomechanics; biomaterials; biomimetics; biomedical diagnostics; biomedical therapy; biomedical devices; sensors and circuits; biomedical imaging and medical information systems; implants and regenerative medicine; neurotechnology; clinical engineering; rehabilitation engineering ● Biochemical engineering and applications: metabolic pathway engineering; modeling and simulation ● Translational bioengineering