First report adsorptive differential pulse voltammetric sensor for sensitive determination of dronedarone in dosage form and biological samples based on tungsten oxide nanostructure: DFT assisted mechanistic insight

IF 5.1 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

BMC Chemistry Pub Date : 2026-08-12 Epub Date: 2026-09-26 DOI:10.1186/s13065-026-01890-2

Rehab Alatawi, Jawza Sh Alnawmasi, Deemah M. Alenazy, Ahmed H. Jawhari, Razan M. Snari, Omer A. Azher, Nasser A. Alamrani, Nashwa M. El-Metwaly

{"title":"First report adsorptive differential pulse voltammetric sensor for sensitive determination of dronedarone in dosage form and biological samples based on tungsten oxide nanostructure: DFT assisted mechanistic insight","authors":"Rehab Alatawi, Jawza Sh Alnawmasi, Deemah M. Alenazy, Ahmed H. Jawhari, Razan M. Snari, Omer A. Azher, Nasser A. Alamrani, Nashwa M. El-Metwaly","doi":"10.1186/s13065-026-01890-2","DOIUrl":null,"url":null,"abstract":"<div><p>The present study illustrated the construction, characterization, and application of a novel tungsten oxide nanoparticle (WO<sub>2</sub>NPs) based sensors for sensitive adsorptive differential pulse voltammetric quantification of dronedarone (DRO) in dosage forms and biological samples. The content of the WO<sub>2</sub>NPs was optimized with full characterization of the surface morphology and the electroanalytical features of the fabricated sensors. At pH 2, DRO molecule recorded an irreversible oxidation peak at 1.08 V following adsorption-controlled mechanism. The molecular orbital calculations and electroanalytical studies sustained the electrooxidation of the nitrogen atom (N5) through the transfer of two-electron/two-proton reaction. Calibration graphs showed linear dynamic range covering the DRO concentration ranged from 0.010 to 2.772 µgmL<sup>− 1</sup>, with LOD value 0.0031 µgmL<sup>− 1</sup>. The developed WO<sub>2</sub>NPs based voltammetric sensor has been successfully applied for the quantification of DRO in biological and pharmaceutical samples. The outcomes were contrasted with the previously reported analytical methods, with the advantages of acceptable performance, wide linear range, and low LOD value. The green assessment of the method acknowledged the environmental friendliness, with the minimal waste generation.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":496,"journal":{"name":"BMC Chemistry","volume":"20 1","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615637/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1186/s13065-026-01890-2","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/9/26 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

The present study illustrated the construction, characterization, and application of a novel tungsten oxide nanoparticle (WO₂NPs) based sensors for sensitive adsorptive differential pulse voltammetric quantification of dronedarone (DRO) in dosage forms and biological samples. The content of the WO₂NPs was optimized with full characterization of the surface morphology and the electroanalytical features of the fabricated sensors. At pH 2, DRO molecule recorded an irreversible oxidation peak at 1.08 V following adsorption-controlled mechanism. The molecular orbital calculations and electroanalytical studies sustained the electrooxidation of the nitrogen atom (N5) through the transfer of two-electron/two-proton reaction. Calibration graphs showed linear dynamic range covering the DRO concentration ranged from 0.010 to 2.772 µgmL^− 1, with LOD value 0.0031 µgmL^− 1. The developed WO₂NPs based voltammetric sensor has been successfully applied for the quantification of DRO in biological and pharmaceutical samples. The outcomes were contrasted with the previously reported analytical methods, with the advantages of acceptable performance, wide linear range, and low LOD value. The green assessment of the method acknowledged the environmental friendliness, with the minimal waste generation.

Graphical Abstract

查看原文本刊更多论文

首次报道了一种基于氧化钨纳米结构的吸附差分脉冲伏安传感器，用于灵敏测定剂型和生物样品：DFT辅助机理。

本研究阐述了一种新型氧化钨纳米颗粒（WO2NPs）传感器的构建、表征和应用，该传感器用于灵敏的吸附差分脉冲伏安法定量drone - edarone （DRO）的剂型和生物样品。优化了WO2NPs的含量，充分表征了所制备传感器的表面形貌和电分析特征。在pH为2时，DRO分子在1.08 V处出现不可逆氧化峰，并遵循吸附控制机制。分子轨道计算和电分析研究支持了氮原子（N5）通过双电子/双质子反应的转移进行电氧化。校正图显示DRO浓度线性动态范围为0.010 ~ 2.772µgmL- 1， LOD值为0.0031µgmL- 1。所研制的基于WO2NPs的伏安传感器已成功应用于生物和制药样品中DRO的定量分析。结果与先前报道的分析方法对比，具有性能可接受，线性范围宽，LOD值低的优点。该方法的绿色评价承认了环境友好，产生的废物最少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Chemistry Chemistry-General Chemistry

CiteScore

5.30

自引率

2.20%

发文量

审稿时长

27 weeks

期刊介绍： BMC Chemistry, formerly known as Chemistry Central Journal, is now part of the BMC series journals family. Chemistry Central Journal has served the chemistry community as a trusted open access resource for more than 10 years – and we are delighted to announce the next step on its journey. In January 2019 the journal has been renamed BMC Chemistry and now strengthens the BMC series footprint in the physical sciences by publishing quality articles and by pushing the boundaries of open chemistry.