Stem cell-derived brain repair for Parkinson’s disease: a review of strategies to improve engraftment

IF 8.5 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2026-09-25 DOI:10.1038/s41531-026-01574-7

Giulia Comini,Mark Denham,Eilís Dowd

引用次数: 0

Abstract

Abstract Induced pluripotent stem cell-derived dopaminergic progenitor transplantation has received conditional approval in Japan for Parkinson’s disease following the Kyoto Phase I/II trial. Early clinical studies demonstrate favourable safety and preliminary efficacy, but interpretation is limited by open-label designs. Preclinical evidence reveals variable graft survival and low differentiation efficiency, highlighting opportunities for optimisation. This review examines strategies to improve survival, differentiation, and functional integration of transplanted dopaminergic progenitors.

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帕金森病的干细胞衍生脑修复：改进植入策略的综述

在京都I/II期临床试验后，诱导多能干细胞衍生的多巴胺能祖细胞移植在日本获得了有条件的批准。早期临床研究显示良好的安全性和初步疗效，但解释受到开放标签设计的限制。临床前证据显示移植物存活率不稳定，分化效率低，突出了优化的机会。本文综述了改善移植多巴胺能祖细胞的存活、分化和功能整合的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.